Results 101 to 110 of about 6,974,500 (303)

Association between COVID-19 Booster Vaccination and COVID-19 Outcomes among U.S. Adults

Vaccines
Understanding the association between booster vaccination and COVID-19 outcomes can help strengthen post-pandemic messaging and strategies to increase vaccination and reduce severe and long-term consequences of COVID-19.
Kimberly H. Nguyen, Cheyenne McChesney, Ruchi Patel, Robert A. Bednarczyk, Lavanya Vasudevan, Laura Corlin   +5 more
doaj   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

ACE2 and COVID-19 Susceptibility and Severity

Aging and disease, 2022
Sick, male, and older populations are more vulnerable to COVID-19. However, it remains unclear whether a common mechanism exists across different demographic characteristics. SARS-CoV-2 infection is initiated by the specific binding of the viral spike protein to angiotensin-converting enzyme 2 (ACE2).
openaire   +2 more sources

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Determinants of COVID-19 severity in Ethiopia: a multicentre case–control study

BMJ Open
Objective It was necessary to understand the determinants of severe COVID-19 in order to deliver targeted healthcare services to prevent further complications and mortality. Identifying the factors associated with severe COVID-19 in Addis Ababa, Ethiopia,
Girma Taye, Yimer Seid Yimer, Manayesh Bantie Tadie   +2 more
doaj   +1 more source

Ruxolitinib and Severe COVID-19

Infection & Chemotherapy, 2021
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit   +1 more
openaire   +2 more sources

COVID-19 and Bangladesh

COVID-19 and Bangladesh analyzes the aftermath of the COVID-19 pandemic and features the socioeconomic fallouts for disadvantaged communities in Bangladesh, their coping mechanisms, and implications for the country’s development ambitions.

core   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

COVID-19 infection and its association with severe malaria & dengue: an epidemiological study from Southern India

BMC Infectious Diseases
Background Post-Coronavirus Disease-19 (COVID-19) sequelae involve complex biological processes that can alter the progression and clinical outcome of other infectious diseases.
Sara J. Ommen, Prasanna Mithra, Rekha T., Nithin Kumar, Ramesh Holla, Naveen Kulal, Mithun Rao, Bhaskaran Unnikrishnan   +7 more
doaj   +1 more source

Hypertension and severe COVID-19

Hypertension Research, 2023
Kow, Chia Siang, Ramachandram, Dinesh Sangarran, Hasan, Syed Shahzad   +2 more
openaire   +2 more sources