Results 241 to 250 of about 6,974,500 (303)

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Low 1,25-dihydroxyvitamin D levels are associated with severe COVID-19: an observational study in hospitalized patients. [PDF]

Front Nutr
Canbolat Unlu E, Karabela SN, Yesilbag Z, Korkusuz R, Borcak D, Salim Dogdas E, Senoglu S, Isiksacan N, Kart Yasar K.   +8 more
europepmc   +1 more source

Early Endoscopic Repair of Traumatic Skull Base Dural Injuries: Challenging the Dogma of Conservative Management

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Traditional management of traumatic skull base dural injury has often favored observation and conservative therapy, despite the risk of delayed intracranial complications. This paradigm originated when operative intervention required craniotomy and carried significant morbidity.
Jessica W. Grayson, Madeline P. Bald, Lauren McLeod, Adam J. Skelton, Nicolaus D. Knight, Do‐Yeon Cho, Justin Turner, Hari Jeyarajan, Kristen O. Riley, Bradford A. Woodworth   +9 more
wiley   +1 more source

Biochemical insights and microRNA profiling via next-generation sequencing in moderate and severe COVID-19 cases. [PDF]

Clinics (Sao Paulo)
Khan M, Altaf A, Ashraf N, Naqvi SZH, Hammad HM, Maqbool T, Aziz T, Alwaili MA, Mohamed RAEH, Alwethaynani MS, Al-Joufi FA, Fallatah D.   +11 more
europepmc   +1 more source

Biologics Adoption in CRSwNP and the Associated Decline in Endoscopic Sinus Surgery: A Longitudinal Claims Database Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Biologic treatments were introduced for chronic rhinosinusitis with nasal polyps (CRSwNP) in 2019. Treatment algorithms for medically refractory CRSwNP remain open, with patients choosing among surgery, biologics, or both. Real‐world utilization of surgery and biologics remains incompletely characterized.
Stephanie Shintani Smith, Sam L. Kaefer, Harsh Duvvuru, Robert C. Kern, Brent A. Senior, Vijay R. Ramakrishnan   +5 more
wiley   +1 more source

Respiratory and bloodstream coinfections and antimicrobial use in hospitalised patients with moderate to severe COVID-19: An Australian retrospective cohort study. [PDF]

PLoS One
Frederiksen L, Subedi S, Choong K, Anderson J, Baird T.   +4 more
europepmc   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Impact of Visceral Fat on Oxygenation Response to Prone Positioning in Mechanically Ventilated Patients With Severe COVID-19. [PDF]

Cureus
Matsui H, Hanafusa M, Kawahara T, Goto Y, Morita A, Tateishi U, Morishita K, Fujiwara T.   +7 more
europepmc   +1 more source

Psychometric Evaluation of the Importance of Olfaction Questionnaire Using Item Response Theory

International Forum of Allergy &Rhinology, EarlyView.
Key Points The IOQ measures the value patients place on olfaction, a construct distinct from disease burden. The IOQ is most precise across the central trait range typical of routine ENT patients. Association items carry most measurement information, enabling a brief affective screen.
Alexander Lein, Bernhard Prem, Christian A. Mueller, David T. Liu   +3 more
wiley   +1 more source

Beyond recovery: long-term cardiovascular risks after severe COVID-19 requiring intensive care. [PDF]

Crit Care
Kämpe J, Jonson M, Rubenson Wahlin R, Hollenberg J, Svensson P, Nordberg P.   +5 more
europepmc   +1 more source