Results 251 to 260 of about 2,311,361 (335)

How Are Australian Local Governments Responding to the Homelessness Crisis? Findings From a National Study

Australian Journal of Social Issues, EarlyView.
ABSTRACT Australian local governments are facing intensifying pressures to respond to worsening visible homelessness. This paper presents one of the first national studies on how local governments are responding to these pressures, and the first since the onset of the post‐pandemic housing crisis.
Andrew Clarke, Joelle Moore, Fatemeh Aminpour, Katya Eagles   +3 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

Integrated humoral and inflammatory signatures predict outcomes in severe COVID-19: a 14-day longitudinal analysis. [PDF]

Clin Transl Immunology
Ibiapina HNS, Magalhães-Gama F, Neves JCF, Alves-Hana FS, Costa-Rocha IA, Lourenço AA, Ribeiro ÁL, Ferreira GM, Fraga-Silva TFC, Paim AAO, Marques DPA, Brito-de-Sousa JP, Campi-Azevedo AC, Peruhype-Magalhães V, Araújo MSS, Teixeira-Carvalho A, Bonato VLD, Becari C, Manegueti MG, Cordeiro-Santos M, Auxiliadora-Martins M, Coelho-Dos-Reis JG, Martins-Filho OA, Costa AG.   +23 more
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

New Simplified White Blood Cells Score Improves Mortality Prediction in Severe COVID-19 Patients. [PDF]

J Clin Med
Paryż K, Lubas A, Gutowski M, Rustecki B, Michałowski A, Klimkiewicz J.   +5 more
europepmc   +1 more source

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Low risk of severe COVID-19 in vaccinated people with multiple sclerosis: a nationwide Norwegian study. [PDF]

BMJ Neurol Open
Rasmussen TH, Schikora-Rustad S, Lorentzen ÅR, Tran TT, Øverås MH, Myhr KM, Wergeland S, Aarseth J, Bø L, Berge T, Høgestøl EA, Harbo HF, Tveter AT, Jørgensen KK, Cunen C, Torkildsen Ø, Holmøy T, Celius EG, Vaage JT, Nygaard GO, Lund-Johansen F, König M.   +21 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Effectiveness and safety of cyclosporine A in moderate to severe COVID-19: a randomized, open-label trial. [PDF]

Sci Rep
Zidan AA, Gad AYS, Zakaria NH, El-Hariri HM, Elsharnouby NM, Helmy MW, El-Setouhy M.   +6 more
europepmc   +1 more source

Electrical Impedance Myography Detects Disease Progression over 12 to 24 Months in Facioscapulohumeral Muscular Dystrophy

Annals of Neurology, EarlyView.
Objective Targeted therapies for facioscapulohumeral muscular dystrophy (FSHD) are progressing through clinical trials. Electrical impedance myography (EIM) provides a noninvasive biomarker of muscle composition that may be valuable especially in early phase trials. This study evaluated EIM data from a multicenter FSHD cohort over 24 months.
Karlien Mul, Michael P. McDermott, Russell J. Butterfield, Bakri Elsheikh, Kate Eichinger, Nicholas E. Johnson, Doris G. Leung, Samantha LoRusso, Leann Lewis, William B. Martens, Perry B. Shieh, Leo H. Wang, Michaela Walker, Rabi Tawil, Jeffrey M. Statland, ReSolve Investigators of the FSHD‐CTRN   +15 more
wiley   +1 more source