Results 251 to 260 of about 6,974,500 (303)

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

Increased impact of GPIb receptors on platelet adhesion under flow in severe COVID-19. [PDF]

Biophys Rep
Avtaeva Y, Guria K, Melnikov I, Kalinskaya A, Artemyeva G, Gabbasov Z.   +5 more
europepmc   +1 more source

Two Years of Ocrelizumab Treatment in Black and Hispanic People with Multiple Sclerosis in CHIMES: A Single‐Arm Clinical Trial

Annals of Neurology, EarlyView.
Objective To evaluate the effectiveness and safety of ocrelizumab in self‐identified black and Hispanic people with relapsing multiple sclerosis. Methods The Characterization of Ocrelizumab in Minorities with Multiple Sclerosis (CHIMES) trial, a prospective, open‐label, single‐arm, phase 4 study, intentionally recruited underrepresented populations in ...
Lilyana Amezcua, Anthony T. Reder, Evanthia Bernitsas, Nancy L. Monson, Timothy Vartanian, Gregory F. Wu, Mansoor Saleh, Annette Okai, Ahmed Z. Obeidat, Dilraj Sokhi, Rikisha Parekh, Jinglan Pei, Christopher Harp, David Clayton, Ibraheem Abioye, Mitzi J. Williams, for the CHIMES Study Group   +16 more
wiley   +1 more source

Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms. [PDF]

Nat Commun
Thurner L, Fadle N, Thurner B, Kos IA, Bewarder M, Regitz E, Bette B, Fischer Y, Lesan V, Rixecker T, Hoffmann MC, Preuss KD, Schormann C, Kaddu-Mulindwa D, Roemer K, Cetin O, Mang S, Becker A, Seiler F, Herr C, Lensch C, Lehmann J, Thiel-Bodenstaff A, Link A, Werner C, Wuchter P, Körper S, Pfuhl T, Lohse S, Rissland J, Thieser K, Pilch J, Papan C, Roth S, Vehreschild JJ, Scherer M, Bröhl I, Wagner P, Witzenrath M, Thibeault C, Haack IA, Mitrov L, Pütz SM, Reese JP, Krawczak M, Hamelmann E, Kopfnagel V, Fiedler K, Geisler R, Valentin H, Stahl D, Hanß S, Ameling S, Völker U, Hansch S, Dörr M, Blaschke S, Braunsteiner J, Dahl E, Pape D, Petersmann A, Stilgenbauer S, Bloos F, Schrezenmeier H, Langer F, Gäbelein G, Friesenhahn-Ochs B, Pfeifer J, Bauer M, Becker SL, Neumann F, Böhm M, Anton G, Kuenne C, Pullamsetti SS, Looso M, Bals R, Smola S, Meybohm P, Krawczyk M, Lepper PM, Kessel C.   +81 more
europepmc   +1 more source

Advancements in CO2 Capture Technologies: A Review of Amine Absorption and Alternative Methods for Post‐Combustion Integration

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Carbon capture technologies are poised to become one of the primary focuses regarding the achievement of net‐zero emissions by the year 2050. In these technologies, particular attention is given to post‐combustion CO2 capture, which is more easily implemented at existing power stations and other industries.
Satyajit Mukherjee, Ashish Kumar, Mayurkumar P. Patil, Rohit B. Meshram   +3 more
wiley   +1 more source

Plasma Ceramides Levels in Severe COVID-19 Disease: Correlations with Survival. [PDF]

Open Forum Infect Dis
Pham T, Heredia Castillo AM, Atkinson A, Peterson LR, Vazquez Guillamet MC.   +4 more
europepmc   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Predicting severe COVID-19 in elderly patients using routine laboratory indicators: Diagnostic accuracy of machine learning models. [PDF]

Medicine (Baltimore)
Lai W, Lin Y, Ou G, Qin X, Yang P, Chen R.   +5 more
europepmc   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Mapping longitudinal lung mycobiome characteristics in severe COVID-19 patients. [PDF]

iScience
Zhang W, Peng C, Gu S, Su X, He G, Han Y, He C, Zhang L, Wang M, Zhong L, Huang L, Jiang C.   +11 more
europepmc   +1 more source