Results 271 to 280 of about 2,311,361 (335)

Histopathological and Immunohistochemical Findings in Postmortem Lungs from Mexican Patients with Severe COVID-19. [PDF]

Int J Mol Sci
Chávez Gómez LG, Ríos Valencia DG, Madrigal-Valencia TL, Hernández Mendoza L, Pérez-Torres A, Tirado Mendoza R.   +5 more
europepmc   +1 more source

Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie, Joseph F. Merola, Philip J. Mease, Christopher T. Ritchlin, Jose U. Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D. Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B. Gottlieb   +12 more
wiley   +1 more source

Proteomic Analysis of Cerebrospinal Fluid from Severe COVID-19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome. [PDF]

Proteomics Clin Appl
Alexopoulos H, Samiotaki M, Gkogkou E, Mavromati S, Bitzogli K, Panagiotou G, Tzioufas A, Magira E, Kotanidou Α, Trougakos I.   +9 more
europepmc   +1 more source

Development of a framework for implementing digital serious games in anatomy education: A single‐centre qualitative study

Anatomical Sciences Education, EarlyView.
Abstract Serious games are emerging as innovative tools in medical education, yet their adoption in anatomy teaching remains limited due to educator hesitancy, institutional constraints, and design challenges. This qualitative study explores the perspectives of anatomy educators on digital serious games and proposes a framework for their implementation.
Arthur Chin Haeng Lau, James Pickering
wiley   +1 more source

Assessing the Impact of Colchicine on Pulmonary Fibrosis Using Imaging in Patients With Moderate-to-Severe COVID-19 Pneumonia. [PDF]

Can Respir J
Ayhan Albayrak G, Bardakci MI, Temel U.
europepmc   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Cytokine Dynamics in Severe COVID-19 vs. Influenza A Elderly Patients: A Prospective Comparative Study. [PDF]

Int J Mol Sci
Rus MA, Huțanu A, Leucuța DC, Briciu VT, Muntean MI, Ionică A, Lupșe MS.   +6 more
europepmc   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Modelling severe COVID-19 in TLR3-mutated hiPSCs-derived lung organoids. [PDF]

Cell Death Discov
Latini A, Spitalieri P, Centofanti F, Rizzacasa B, Amatore D, Grilli G, De Santis R, Vaccaro L, Colona VL, Puleri G, Nardone AM, Biancolella M, Campione E, Sarmati L, Rogliani P, Cacchiarelli D, Novelli A, Sangiuolo F, Lista F, Novelli G.   +19 more
europepmc   +1 more source