Results 291 to 300 of about 2,311,361 (335)

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir–ritonavir in patients with COVID‐19

British Journal of Clinical Pharmacology, EarlyView.
Aims The repurposed use of favipiravir in COVID‐19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans.
Akosua A. Agyeman, Laura Buggiotti, Li‐An K. Brown, Jose A. Guerra‐Assuncao, Japhette E. Kembou‐Ringert, Wen Y. Mak, Judith Breuer, David M. Lowe, Joseph F. Standing, FLARE Investigators   +9 more
wiley   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

IFNAR2 p.F8S Variant Associates with Severe COVID-19 and Adaptive Immune Cell Activation Modulation. [PDF]

Int J Mol Sci
Malvestiti F, Lombardi A, Gentile F, Torcianti V, Trombetta E, Cherubini A, Lamorte G, Uceda Renteria SC, Marchelli D, Rosso L, Bandera A, Peyvandi F, Blasi F, Grasselli G, Porretti L, Alqahtani S, Prati D, Gualtierotti R, Soskic B, Vaira V, Ronzoni L, Valenti L.   +21 more
europepmc   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

“The purpose of activism is to educate”: Young people's climate activism as and for education in the youth strike movement in England

British Educational Research Journal, EarlyView.
Abstract By skipping school for their cause, young climate strikers repeatedly demonstrated their priorities in 2019 and 2020. They regularly chose to sacrifice a day of their formal education in favour of collective action. This study asks what we can learn from the reflections of former youth strikers.
Loz J. Hennessy
wiley   +1 more source

Sustaining the teaching profession: Innovating the ‘golden thread’ in university‐led teacher education

British Educational Research Journal, EarlyView.
Abstract This paper examines the implications of England's ‘golden thread’ policy framework for teacher education, which describes a state‐mandated, linear model of professional learning from initial teacher training and education through to continuing professional development.
Amanda Nuttall, Ed Podesta, Aimee Quickfall, Megan Stephenson   +3 more
wiley   +1 more source

Antiphospholipid Antibodies in Severe COVID-19: Frequency, Clinical Features, and 12-Week Follow-Up. [PDF]

Cureus
Hasan MN, Chowdhury FR, Islam KMK, Sami CA, Islam MT.   +4 more
europepmc   +1 more source

Teacher‐makers and teacher‐breakers: (Re)defining how status and safety influence trajectories into and away from teaching

British Educational Research Journal, EarlyView.
Abstract This paper uses empirical data from a longitudinal qualitative study conducted with aspirant teachers in England to propose (re)definitions of the concepts of ‘status’ and ‘safety’ as a framework with which to understand and improve teacher recruitment.
Emily MacLeod
wiley   +1 more source

Risk factors for severe COVID-19 and development of a predictive model. [PDF]

BMC Pulm Med
Zhang L, Li X, Wang Z, Zhao L, Gao H, Liu C, Bai J, Liu T, Chen W, Li W, Bai J, Fu A, Ge Y.   +12 more
europepmc   +1 more source