Results 51 to 60 of about 6,974,500 (303)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

COVID‐19 Vaccine‐Induced Severe Pneumonitis

Respirology Case Reports
Coronavirus disease 2019 (COVID‐19) has resulted in global morbidity, mortality, and societal disruption. COVID‐19 mRNA vaccination was mandatory in many countries for a period; however, severe adverse events have been observed in some individuals who ...
Tatsuro Suzuki, Hiromi Furuta, Misa Naganawa, Keiko Hayashi, Hiroko Kiyotoshi, Chiharu Ohta, Shigemitsu Ninomiya   +6 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Severe infectious acute respiratory failure mimicking COVID‐19 in a healthy adolescent

Respirology Case Reports, 2022
A 15‐year‐old male presented with headache, high fever and respiratory distress. Chest computed tomography showed bilateral pneumonia, and antimicrobial therapy was initiated.
Kohei Hashimoto, Takako Kawaguchi, Kei Yamasaki, Hiroaki Ikegami, Toshinori Kawanami, Kazuhiro Yatera   +5 more
doaj   +1 more source

Hypolipidemia is associated with the severity of COVID-19 [PDF]

Journal of Clinical Lipidology, 2020
Many patients with coronavirus disease 2019 (COVID-19) suffer multiple organ dysfunctions. However, whether patients develop dyslipidemia is unknown.In this study, we aimed to investigate the pathological alterations of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and total cholesterol (TC) in COVID-19 ...
Wei, Xiuqi, Zeng, Wenjuan, Su, Jingyu, Wan, Huimin, Yu, Xinqin, Cao, Xiaoling, Tan, Wenbin, Wang, Hui   +7 more
openaire   +2 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo [PDF]

, 2022
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already caused 6 million deaths worldwide. While asymptomatic individuals are responsible of many potential transmissions, the difficulty to identify and isolate them at the high
Durán Ruiz, María del Carmen, de la Torre, Ines Garcia, Moreno-Luna, Rafael, Eslava Alcón, Sara, Rojas Torres, Marta, Sanchez-Morillo, Daniel, Martinez-Nicolas, Mª Pilar, Martin-Bermejo, Victoria, Martinez‑Nicolás, Mª Pilar, Martín‑Bermejo, Victoria, Rojas-Torres, Marta, Eslava-Alcon, Sara, Duran-Ruiz, Mª Carmen, Moreno, Juan Antonio, Sánchez Morillo, Daniel, Moreno Luna, Rafael, Beltran-Camacho, Lucia, Berrocoso, Esther, Berrocoso Domínguez, Esther María, Beltrán Camacho, Lucía, García de la Torre, Inés   +20 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study

Respiratory Research, 2020
Background Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved.
Houwei Du, Xiaobin Pan, Nan Liu, Junnian Chen, Xiaoling Chen, David J. Werring, Gareth Ambler, Xiaoqing Li, Ronghua Chen, Yixian Zhang, Huayao Huang, Feifei Lin, Pincang Xia, Chao Chen, Zhenyang Zheng, Sangru Wu, Hanhan Lei, Lei Gao, Mingxu Huang, Kexu Lin, Xiaoping Xu, Yukun Luo, Ziwen Zhao, Chen Li, Hailong Lin, Yu Lin, Zhenghui Huang, Rongxiang Cao, Limin Chen, On behalf of the Fujian Medical Team Support Wuhan for COVID-19   +29 more
doaj   +1 more source