Results 61 to 70 of about 43,151 (205)

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, EarlyView.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

Early prognosis biomarkers of severe fever with thrombocytopenia syndrome

iLABMED
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that results from SFTS bunyavirus (SFTSV) infection. Infection with SFTSV can activate the immune system, producing a series of inflammatory factors.
Mingrong Ou, Aofan Wang, Jie Yu, Liwei Zhao, Chuang Li, Yuanyuan Wu, Yuxin Chen   +6 more
doaj   +1 more source

Transmission of Severe Fever with Thrombocytopenia Syndrome Virus by Haemaphysalis longicornis Ticks, China

Emerging Infectious Diseases, 2018
We demonstrate maintenance and transmission of severe fever with thrombocytopenia syndrome virus by Haemaphysalis longicornis ticks in the larva, nymph, and adult stages with dissemination in salivary gland, midgut, and ovarian tissues.
Lu Zhuang, Yi Sun, Xiao-Ming Cui, Fang Tang, Jian-Gong Hu, Li-Yuan Wang, Ning Cui, Zhen-Dong Yang, Dou-Dou Huang, Xiao-Ai Zhang, Wei Liu, Wu-Chun Cao   +11 more
doaj   +1 more source

Predictors for intrapartum cesarean delivery after labor induction for suspected fetal growth restriction at term

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective In term pregnancies with suspected fetal growth restriction (FGR) undergoing induction of labor (IOL), predictors for intrapartum cesarean delivery (CD) remain unclear. We aimed to determine predictors for intrapartum CD in this population. Methods This study included a retrospective cohort of singleton pregnancies undergoing IOL at ≥
Matan Anteby, Yael Reichman, Alon Bar‐Or, Jacky Herzlich, Stav Cohen, Karina Krajden Haratz, Anat Lavie, Liran Hiersch, Yariv Yogev   +8 more
wiley   +1 more source

RNA viral protein structure database: A comprehensive and user‐friendly web database for RNA viral protein structures

iMetaOmics, EarlyView.
Given the central role of protein structures in RNA virus biology, the RNA viral protein structure database (RVPSD, https://virus.9itsg.net) integrates taxonomic classification, viral nucleotide and protein sequences, functional annotations, and predicted three‐dimensional protein structures.
Qiangzhen Yang, Zhongshuai Tian, Tao Hu, Jiangrong Lou, Hengcong Liu, Edward C. Holmes, Yongyong Shi, Juan Li, Weifeng Shi   +8 more
wiley   +1 more source

A retrospective survey of the seroprevalence of severe fever with thrombocytopenia syndrome virus in wild animals in Japan

Veterinary Medicine and Science, 2021
Severe fever with thrombocytopenia syndrome (SFTS) has a high fatality rate and is caused by SFTS virus (SFTSV). Currently, SFTS is endemic to some areas in western Japan, and wild animals are considered to play important roles in the circulation of ...
Ayaka Okada, Akitoyo Hotta, Masanobu Kimura, Eun‐sil Park, Shigeru Morikawa, Yasuo Inoshima   +5 more
doaj   +1 more source

Severe fever thrombocytopenia syndrome proceeding east

Journal of Rural Medicine
Severe fever thrombocytopenia syndrome (SFTS) is a tick-borne viral hemorrhagic fever prevalent throughout Asia. In 2024, our hospital in eastern Shizuoka reported three consecutive cases of SFTS, the first such cluster identified in this region. Since April 2013, the confirmed area of infection has expanded from Kyushu to Shizuoka, which currently ...
Yanagawa, Youichi, Nagasawa, Hiroki, Shimizu, Yoshio   +2 more
openaire   +2 more sources

Correlation between thrombocytopenia and host response in severe fever with thrombocytopenia syndrome

PLOS Neglected Tropical Diseases, 2020
Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus, SFTS virus (SFTSV), with fatal outcome developed in approximately 17% of the cases. Thrombocytopenia is a hallmark feature of SFTS, and associated with a higher risk of fatal outcome, however, the pathophysiological involvement of platelet
Xiao-Kun Li, Ke Dai, Zhen-Dong Yang, Chun Yuan, Ning Cui, Shao-Fei Zhang, Yuan-Yuan Hu, Zhi-Bo Wang, Dong Miao, Pan-He Zhang, Hao Li, Xiao-Ai Zhang, Yan-Qin Huang, Wei-Wei Chen, Jiu-Song Zhang, Qing-Bin Lu, Wei Liu   +16 more
openaire   +4 more sources

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source