Results 81 to 90 of about 2,042,286 (309)

Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial

Cancer Communications, Volume 45, Issue 4, Page 442-455, April 2025.
Abstract Background The prognosis for non‐small cell lung cancer (NSCLC) patients treated with standard platinum‐based chemotherapy was suboptimal, with safety concerns. Following encouraging results from a preliminary phase I study, this phase II trial investigated the efficacy and safety of first‐line sintilimab and anlotinib in metastatic NSCLC ...
Tianqing Chu, Hua Zhong, Zhuang Yu, Jing Wang, Yanqiu Zhao, Xiaoqian Mu, Xinmin Yu, Xun Shi, Qingming Shi, Maojing Guan, Cuimin Ding, Nan Geng, Jialin Qian, Baohui Han   +13 more
wiley   +1 more source

Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. [PDF]

, 2019
BackgroundRapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs ...
Goldstein RE, Grauer GF, Kalish RA, Levy S, Levy SA, Rolla D, Scorpio DG   +6 more
core   +1 more source

Prognostic Factors of Severe Fever with Thrombocytopenia Syndrome in South Korea [PDF]

Viruses, 2020
Severe fever with thrombocytopenia syndrome (SFTS), a tick-borne infectious disease, is difficult to differentiate from other common febrile diseases. Clinically distinctive features and climate variates associated with tick growth can be useful predictors for SFTS.
Misun Kim, Sang Taek Heo, Hyunjoo Oh, Suhyun Oh, Keun Hwa Lee, Jeong Rae Yoo   +5 more
openaire   +4 more sources

Pirtobrutinib in Chinese patients with relapsed or refractory B‐cell malignancies: A single‐arm, open‐label, phase 2, multicenter trial

International Journal of Cancer, Volume 156, Issue 11, Page 2158-2168, 1 June 2025.
What's new? Pirtobrutinib, a highly selective, noncovalent (reversible) Bruton tyrosine kinase inhibitor (BTKi), has shown promise in treating patients with B‐cell malignancies following treatment with covalent BTKis. However, potential geographic and ethnic differences in patient response to pirtobrutinib remain to be clarified.
Yanyan Liu, Ningjing Lin, Shuhua Yi, Huiqiang Huang, Ye Guo, Qingyuan Zhang, Haiyan Yang, Huilai Zhang, Liling Zhang, Ru Feng, Yijiao Qian, Jiankun Zhu, Yuqin Song, Jun Zhu   +13 more
wiley   +1 more source

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +1 more source

Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia [PDF]

, 2018
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Alfaraj, Sarah H., Altuwaijri, Talal A., Memish, Ziad A.   +3 more
core   +1 more source

Severe fever with thrombocytopenia syndrome-associated encephalopathy/encephalitis [PDF]

Clinical Microbiology and Infection, 2018
Severe fever with thrombocytopenia syndrome (SFTS) virus has a variety of central nervous system (CNS) manifestations. However, there are limited data regarding SFTS-associated encephalopathy/encephalitis (SFTSAE) and its mechanism.All patients with confirmed SFTS who underwent cerebrospinal fluid (CSF) examination due to suspected acute encephalopathy
Taeeun Kim, Sun-Mi Kim, Ji-Soo Kwon, Sung-Han Kim, Yang Soo Kim, Sang-Ho Choi, Sang-Oh Lee, Ji-Yeun Kim, Se Yoon Park, Yong Pil Chong, Oh-Hyun Cho, Yong Rock Jang, Jun Hee Woo, Min-Chul Kim   +13 more
openaire   +3 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Transmission of Severe Fever with Thrombocytopenia Syndrome Virus by Haemaphysalis longicornis Ticks, China

Emerging Infectious Diseases, 2018
We demonstrate maintenance and transmission of severe fever with thrombocytopenia syndrome virus by Haemaphysalis longicornis ticks in the larva, nymph, and adult stages with dissemination in salivary gland, midgut, and ovarian tissues.
Lu Zhuang, Yi Sun, Xiao-Ming Cui, Fang Tang, Jian-Gong Hu, Li-Yuan Wang, Ning Cui, Zhen-Dong Yang, Dou-Dou Huang, Xiao-Ai Zhang, Wei Liu, Wu-Chun Cao   +11 more
doaj   +1 more source

Identification of severe fever with thrombocytopenia syndrome virus genotypes in patients and ticks in Liaoning Province, China

Parasites & Vectors, 2022
Background Severe fever with thrombocytopenia syndrome (SFTS), caused by the SFTS virus (SFTSV), is an acute infectious disease transmitted by ticks that has recently been identified.
Xiao-Hu Han, Yue Ma, Hong-Yan Liu, Dan Li, Yan Wang, Feng-Hua Jiang, Qing-Tian Gao, Feng Jiang, Bao-Shan Liu, Guo-Shun Shen, Ze-Liang Chen   +10 more
doaj   +1 more source