ABSTRACT Background Brain MRI is widely performed in children with short stature or suspected growth hormone deficiency(GHD) to exclude hypothalamic–pituitary (HP) pathology, yet its diagnostic yield in routine practice is uncertain. We aimed to evaluate the prevalence, clinical significance, and distribution of HP and extrahypothalamic abnormalities ...
Mustafa Zubeidat +2 more
wiley +1 more source
Cortisol Cutoffs for Adrenal Insufficiency Using Elecsys II: A Systematic Review
ABSTRACT Objective Adrenal insufficiency (AI) is associated with increased risk of morbidity and mortality if improperly managed. Adrenocorticotrophin (ACTH) stimulation testing is the most widely used AI diagnostic test. Historically, a serum cortisol threshold of 500 nmol/L (18.1 µg/dL), derived using polyclonal assays, was widely used.
Sarah Haunton +7 more
wiley +1 more source
Diabetic Ketoacidosis and Severe Hypoglycemia Risks with Ipragliflozin/Insulin Versus Insulin in Type 1 Diabetes: A Japanese Real-World Database Study. [PDF]
Kawamura T +4 more
europepmc +1 more source
ABSTRACT Objectives Insulinoma is a predominantly benign pancreatic neuroendocrine tumour that is traditionally managed surgically. However, surgical invasiveness and anaesthesia‐related risks limit its applicability in selected patients. Endoscopic ultrasound (EUS)‐guided ethanol ablation has emerged as a minimally invasive alternative.
Yuchao Wu +15 more
wiley +1 more source
NICTH with secondary acromegaloid changes and severe hypoglycemia due to potentially insulin-like growth factor-2 mediated effects. [PDF]
Fatollahzadeh M +3 more
europepmc +1 more source
Expanding the Biochemical Phenotype of ReNU Syndrome: A Case Report
This report detailed the clinical findings and the biochemical phenotype of a 3‐year‐old girl with ReNU syndrome. Circulating biomarkers and a muscle biopsy s uggested mild mitochondrial abnormalities. Severe plasmalogen deficiency was also observed, comparable to defects of peroxisomal plasmalogen biosynthesis.
Irene De Biase +4 more
wiley +1 more source
The Relationship Between the Percent Coefficient of Variation of Sensor Glucose Levels and the Risk of Severe Hypoglycemia or Non-Severe Hypoglycemia in Patients With Type 1 Diabetes: Post Hoc Analysis of the ISCHIA Study. [PDF]
Murata T +16 more
europepmc +1 more source
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet +3 more
wiley +1 more source
Poor sleep quality is a predictor of severe hypoglycemia during comprehensive diabetes care in type 1 diabetes. [PDF]
Dejkhamron P +9 more
europepmc +1 more source
Abstract Aim To determine the best combination of perinatal characteristics, socioenvironmental factors, and neurological examination at term‐equivalent age for identifying motor delay at 3 months 2 weeks corrected age in infants born preterm between 29 weeks and 36 weeks of gestation.
Melanie Gagnon +8 more
wiley +1 more source

