Results 111 to 120 of about 2,972,520 (248)

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Engineering an Artificial Metalloenzyme for Efficient Photo‐Enzymatic CO2 Conversion

Advanced Science, EarlyView.
We built a light‐driven artificial metalloenzyme by covalently conjugating formate dehydrogenase (FDH) with a tailored rhodium complex (Rh‐L6) to overcome spatial‐separation‐limited electron transfer. This integration boosts NADH regeneration and CO2 conversion, giving 2.31‐fold higher formate yield than physical mixtures, due to a narrowed bandgap and
Mengxue Kang, Yan Chu, Zhichun Xu, Jiao Feng, Ganlu Li, Kequan Chen, Hui Li   +6 more
wiley   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Key drilling and completion technologies for the fengye-1 well in the Guizhong Depression, Dian-Qian-Gui Basin

Youqicang pingjia yu kaifa
Well Fengye 1 is the first shale gas risk exploration well deployed by Jiangsu Oilfield in the Huangui-Liuzhou karst cave development zone, aiming to obtain shale parameters of the Lugaizai Formation in the Fengshan Syncline and evaluate the regional ...
SUN YUEDONG, DOU ZHENGDAO, ZHAO JIN, HU ZHONGTAO, LI QILONG, CHEN XIAOYUAN   +5 more
doaj  

Study on Wellbore Instability Mechanism of Continental Shale Reservoir in Northeastern Sichuan Basin

Zuanjingye yu wanjingye
Shale reservoirs in the Qianfoya continental facies shale reservoirs in northeastern Sichuan collapsed seriously, leading to severe difficulties in drilling a well successfully.
Shuyang GAO, Kehao BO, Yayun ZHANG, Hong GAO, Jinglong HUANGFU   +4 more
doaj   +1 more source

Lost Circulation Problems and Solutions

, 2014
The basic outline of the project focuses on problems seen in the field due to lost circulation of drilling fluids in the wellbore. This is one of the biggest contributors to non-productive time while drilling a well. In the oil industry, any time lost is
Thibodeaux, Garrett
core  

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Progress in The Lost Circulation Technology Development Program

, 1991
Lost circulation is the loss of drilling fluid from the wellbore to fractures or pores in the rock formation. In geothermal drilling, lost circulation is often a serious problem that contributes greatly to the cost of the average geothermal well.
Wright, E. K., Schafer, D. M., Loeppke, G. E., Glowka, D. A.   +3 more
core