Results 101 to 110 of about 4,253,715 (400)

Improvements in Health‐Related Quality of Life With Treat‐to‐Target Urate‐Lowering Therapy in Gout: A Post Hoc Analysis of a Randomized Multicenter Trial

Arthritis Care &Research, EarlyView.
Objective Although treat‐to‐target urate‐lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health‐related quality of life (HRQoL). We assessed the impact of treat‐to‐target ULT on HRQoL among participants receiving protocolized gout care, identifying factors associated with HRQoL and HRQoL ...
Austin Barry, Bryant R. England, Harlan Sayles, Lindsay N. Helget, Maria Androsenko, Hongsheng Wu, Kaleb Michaud, Bridget Kramer, Jeff A. Newcomb, Mary T. Brophy, Anne Davis‐Karim, Ryan Ferguson, Michael H. Pillinger, Tuhina Neogi, Paul M. Palevsky, James R. O'Dell, Ted R. Mikuls   +16 more
wiley   +1 more source

Novel Mutations in Obesity-related Genes in Turkish Children with Non-syndromic Early Onset Severe Obesity: A Multicentre Study

JCRPE, 2019
Objective:Non syndromic monogenic obesity is a rare cause of early onset severe obesity in the childhood period. This form may not be distinguishable from other forms of severe obesity without genetic analysis, particularly if patients do not exibit any ...
Ayşehan Akıncı, Doğa Türkkahraman, İbrahim Tekedereli, Leyla Özer, Bahri Evren, İbrahim Şahin, Tarkan Kalkan, Yusuf Çürek, Emine Çamtosun, Esra Döğer, Aysun Bideci, Ayla Güven, Erdal Eren, Özlem Sangün, Atilla Çayır, Pelin Bilir, Ayça Törel Ergür, Oya Ercan   +17 more
doaj   +1 more source

Long‐Term Opioids in Gout: A Matched Cohort Study From the Veterans Health Administration

Arthritis Care &Research, EarlyView.
Objective Though used frequently to treat flare, risk of long‐term opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed long‐term opioids over time.
Lindsay N. Helget, Bryant R. England, Punyasha Roul, Harlan Sayles, Tuhina Neogi, James R. O'Dell, Joshua F. Baker, Ted R. Mikuls   +7 more
wiley   +1 more source

The role of nitro oxidative factors in metabolic dysfunctions: A link between severe obesity and weight-loss treatment – a narrative review

Romanian Journal of Laboratory Medicine
Introduction: Metabolic syndrome (MS) is linked to oxidative stress and intracellular redox imbalance, both triggered by chronic inflammatory conditions.
Ion Razvan Marius, Sibianu Melania, Neagoe Radu, Sala Daniela, Beresescu Felicia, Daniealopol Valentin, Daniealopol Ruxandra, Muresan Mircea   +7 more
doaj   +1 more source

Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement.

American Journal of Physiology. Endocrinology and Metabolism, 2019
The gut bacterial species, Akkermansia muciniphila is associated with a healthier clinical profile. The purpose of this study was to determine the association between A.
M. Dao, Eugeni Belda, Edi Prifti, A. Everard, B. Kayser, J. Bouillot, J. Chevallier, N. Pons, E. Le Chatelier, D. Ehrlich, J. Dore, J. Aron‐Wisnewsky, Jean-Daniel Zucker, Patrice D Cani, K. Clément   +14 more
semanticscholar   +1 more source

Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Prevalence of Drug Interaction in Severely Obese Individuals and Associated Factors: Baseline Results from a Clinical Trial

Scientia Pharmaceutica, 2020
The prevalence of obesity is increasing worldwide and is commonly associated with comorbidities. The use of several drugs is often necessary, which leads to Potential Drug Interactions (PDI) that may increase the morbidity and mortality. This study aimed
Ana Carolina Figueiredo Modesto, Erika Aparecida Silveira, Ana Paula dos Santos Rodrigues, Dione Marçal Lima, Mércia Pandolfo Provin, Rita Goreti Amaral   +5 more
doaj   +1 more source

Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation [PDF]

, 2016
Obesity is recognized as an important risk factor for the development of many chronic diseases such as hypertension, Type 2 diabetes mellitus (T2DM) cardiovascular disease, cancer, renal disease, neurologic dysfunction, metabolic syndrome and asthma (3 ...
Bradley, Jennifer L
core   +1 more source

Self-reported psychosocial health in obese patients before and after weight loss [PDF]

, 2010
Psychosocial profiles were examined in 255 morbidly obese patients attending a hospital service offering access to standard weight loss therapies. 129 patients were reassessed after at least 6-month follow-up.
Kumar, Sudhesh, Kyrou, Ioannis, Matyka, Krystyna, Osei-Assibey, G., Saravanan, Ponnusamy   +4 more
core   +4 more sources