Results 151 to 160 of about 628,141 (359)

A Major Predisposition Locus for Severe Obesity, at 4p15-p14 [PDF]

, 2002
Steven Stone, Victor Abkevich, Steven C. Hunt, Alexander Gutin, Deanna L. Russell, Chris Neff, Robyn Riley, Georges C. Frech, Charles H. Hensel, Srikanth Jammulapati, Jennifer Potter, David Sexton, Thanh V. Tran, Drew Gibbs, Diana Iliev, Richard E. Gress, Brian T. Bloomquist, John M. Amatruda, M.M. Peter Rae, D. Adams, H. Mark Skolnick, Donna Shattuck   +21 more
openalex   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

A Novel Homozygous Missense Mutation of Melanocortin-4 Receptor (MC4R) in a Japanese Woman With Severe Obesity [PDF]

, 2002
Hiromasa Kobayashi, Yoshihiro Ogawa, Mitsuyo Shintani, Ken Ebihara, Makiko Shimodahira, Toshio Iwakura, Megumu Hino, Takashi Ishihara, K Ikekubo, Hiroyuki Kurahachi, Kazuwa Nakao   +10 more
openalex   +1 more source

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

A Novel Melanocortin 3 Receptor Gene (MC3R) Mutation Associated with Severe Obesity [PDF]

, 2002
Yung Seng Lee
openalex   +1 more source

Bariatric Surgery as a Treatment to Obesity [PDF]

, 2019
This paper focuses on the efficiency and effectiveness that bariatric surgery provides as a treatment for the obesity epidemic that is ever-growing in our country. By taking into account scientific, ethnographical, scholarly, statistic-based, and various
Dunn, Morgan D
core   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Impact of Severe Obesity on Outcomes in Single-Level Anterior Cervical Discectomy and Fusion (ACDF): A Large-Scale Comparative Study

Surgical Techniques Development
Background: Anterior cervical discectomy and fusion (ACDF) is a common procedure for cervical radiculopathy and myelopathy. Severe obesity (BMI ≥ 40 or BMI ≥ 35 with comorbidities) is associated with increased perioperative risks. This study examines the
David Maman, Ofek Bar, Yaniv Steinfeld, Ali Sleiman, Arsen Shpigelman, Lior Ben Zvi, Yaron Berkovich   +6 more
doaj   +1 more source

A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity [PDF]

, 2003
Frederick F. Samaha, Nayyar Iqbal, Prakash Seshadri, Kathryn L. Chicano, Denise A. Daily, Joyce McGrory, Terrence T. Williams, Monica Williams, Edward J. Gracely, Linda Stern   +9 more
openalex   +1 more source