Results 131 to 140 of about 2,020,313 (253)
Obesity and Malnutrition in a Shantytown Population in the City of São Paulo, Brazil
, 1995 To investigate the prevalence of obesity and malnutrition in the poor Brazilian population we conducted a the socioeconomic and nutritional status of 535 families (comprising 2 411 individuals) living in shanty towns in the city of Sao Paulo, There was a
Ventura, Maria Luisa Pereira [UNIFESP] +6 more
core +1 more source
Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies
Advanced Science, EarlyView.This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan +5 more
wiley +1 more source
Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM
Cell GenomicsSummary: Polygenic severe obesity (body mass index [BMI] ≥40 kg/m2) has increased, especially in Hispanic/Latino populations, yet we know little about the underlying mechanistic pathways.
Hung-Hsin Chen +38 more
doaj +1 more source
Profile of High Obesity Areas in: Indiana [PDF]
Obesity is a major health problem on a national level, butcertain areas in the United States experience a much higherburden of the disease. The Centers for Disease Control andPrevention\u2019s (CDC) Division of Nutrition, Physical Activity, andObesity ...
core
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
Journal of Minimal Access SurgeryIntroduction: Ventral hernia (VH) in patients with severe obesity poses a surgical challenge during bariatric surgery (BS). There is conflicting evidence regarding the optimal timing to perform a definitive VH repair (VHR).
Sonali Mittal +4 more
doaj +1 more source
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
Severe obesity is not a ‘mild disease’ [PDF]
Anaesthesia and Intensive Care, 2020 openaire +2 more sources
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia
Advanced Science, EarlyView.The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian +12 more
wiley +1 more source