Results 31 to 40 of about 2,020,313 (253)

HOMA-IR as a Predictor of PAI-1 Levels in Women with Severe Obesity

Biomedicines
Background: Obesity is a chronic inflammatory disorder that increases the risk of cardiovascular diseases (CVDs). Given the high CVD mortality rate among individuals with obesity, early screening should be considered. Plasminogen activator inhibitor (PAI-
Fabiana Martins Kattah, Milijana Janjusevic, Nayra Figueiredo, Emilly Santos Oliveira, Glaucia Carielo Lima, Ana Raimunda Dâmaso, Lila Missae Oyama, Alessandra Lucia Fluca, Paulo Reis Eselin de Melo, Maria Aderuza Horst, Aneta Aleksova, Flávia Campos Corgosinho   +11 more
doaj   +1 more source

Performance of Biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in Patients with Severe Obesity: Meta Analysis of Individual Patient Data [PDF]

, 2012
Background Liver biopsy is considered as the gold standard for assessing non-alcoholic fatty liver disease (NAFLD) histologic lesions in patients with severe obesity.
Mathurin, Philippe, Karine Clement (2245), Poynard, Thierry, Charlotte, Frederic, Guillaume Lassailly, Emmanuel Diaz, Philippe Mathurin (177542), Caıazzo, Robert, Demol, Bernard, Tordjman, Joan, Guillaume Lassailly (177527), François Pattou, Pierre Bedossa, Perazzo Hugo, Vlad Ratziu (38088), Robert Callafe (177536), Bedossa, Pierre, Ratziu, Vlad, Clement Karine, Charlotte Frederic, Munteanu Mona, Bernard Demol (177533), Pattou, François, FLIP consortium, Frederic Charlotte (43075), Pierre Bedossa (48266), Emmanuel Diaz (177528), Thierry Poynard (38084), Lassailly, Guillaume, Joan Tordjman (48258), Lassailly Guillaume, Bernard Demol, Mathurin Philippe, Tordjman Joan, Frederic Charlotte, Clement, Karine, Karine Clement, Joan Tordjman, Robert Caïazzo (177530), Perazzo, Hugo, Mona Munteanu (38097), Bedossa Pierre, Philippe Mathurin, Ratziu Vlad, Thierry Poynard, Mona Munteanu, Callafe Robert, Pattou François, Robert Caïazzo, Diaz Emmanuel, Hugo Perazzo (143739), Demol Bernard, Caïazzo Robert, Callafe, Robert, Munteanu, Mona, Diaz, Emmanuel, Hugo Perazzo, Robert Callafe, Vlad Ratziu, François Pattou (145757), Poynard Thierry   +60 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Oligogenic inheritance in severe adult obesity [PDF]

Data availability: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.Supplementary information is available onlne at: https://www.nature.com/articles/s41366-024 ...
Blakemore, AIF, Nor Hashim, NA, Yiorkas, AM, Walters, RG, Almansoori, S, Chahal, HS, Purkayastha, S, Alsters, SI, Lessan, N   +8 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Prevalence of Drug Interaction in Severely Obese Individuals and Associated Factors: Baseline Results from a Clinical Trial

Scientia Pharmaceutica, 2020
The prevalence of obesity is increasing worldwide and is commonly associated with comorbidities. The use of several drugs is often necessary, which leads to Potential Drug Interactions (PDI) that may increase the morbidity and mortality. This study aimed
Ana Carolina Figueiredo Modesto, Erika Aparecida Silveira, Ana Paula dos Santos Rodrigues, Dione Marçal Lima, Mércia Pandolfo Provin, Rita Goreti Amaral   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Trends and Subgroup Comparisons of Obesity and Severe Obesity Prevalence Among Mississippi Adults, 2011–2021

Obesities
Mississippi has long been one of the most obese states in the U.S., with its obesity rates consistently exceeding the national average. The state’s severe obesity rate is also among the highest in the nation.
Stephanie McLeod, Xiaoshan Z. Gordy, Jana Bagwell, Christina Ferrell, Jerome Kolbo, Lei Zhang   +5 more
doaj   +1 more source

A Rare Potential Pathogenic Variant in the BDNF Gene is Found in a Brazilian Patient with Severe Childhood-Onset Obesity

Diabetes, Metabolic Syndrome and Obesity, 2021
Ana Carolina Proença da Fonseca,1,2 Gabriella de Medeiros Abreu,2 Lohanna Palhinha,1 Verônica Marques Zembrzuski,2 Mario Campos Junior,2 João Regis Ivar Carneiro,3 José Firmino Nogueira Neto,4 Fernanda Cristina C Mattos Magno,5
da Fonseca ACP, Abreu GM, Palhinha L, Zembrzuski VM, Campos Junior M, Carneiro JRI, Nogueira Neto JF, Magno FCCM, Rosado EL, Maya-Monteiro CM, Cabello GMK, Cabello PH, Bozza PT   +12 more
doaj