Results 101 to 110 of about 3,781,222 (303)

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality [PDF]

, 2017
Background With the aim of populating the Lives Saved Tool (LiST) with parameters of effectiveness of existing interventions, we conducted a systematic review of the literature assessing the effect of Haemophilus influenzae type b (Hib) and pneumococcal (
Bhopal, Sunil, Boschi-Pinto, Cynthia, Campbell, Harry, Clark, Andrew, Jhass, Arnoupe, Johnson, Sue, Madhi, Shabir A., Rudan, Igor, Theodoratou, Evropi   +8 more
core  

Empiric Antibiotic Therapy in the Treatment of Community-acquired Pneumonia in a General Hospital in Saudi Arabia [PDF]

, 2019
Background: Guideline-based empiric antimicrobial therapy is recommended for the treatment of community-acquired pneumonia (CAP). In this study, we evaluate the pattern of empiric antibiotics of CAP patients.
Al-Tawfiq, Jaffar A., Hinedi, Kareem, Momattin, Hisham   +2 more
core   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Clinical value of dysregulated miR-125b-5p in severe pneumonia children

BMC Immunology
Background Severe pneumonia is an important contributor to the high mortality of sick young children. The microRNA-125b-5p (miR-125b-5p), which is widely involved in various cancers, is closely related to a variety of lung diseases.
Meiqin Zhu, Ziyan Lu, Xingjuan Liao, Qin Liang, Chao Xu, Xinbing Luo, Jun Li   +6 more
doaj   +1 more source

Recommendations for diagnosing and treating severe Mycoplasma pneumoniae pneumonia in children: clinical practice protocols from the Third Affiliated Hospital of Sun Yat-sen University [PDF]

Xin yixue
Mycoplasma pneumoniae pneumonia （MPP） is a common cause of community-acquired pneumonia in children aged 5 and older in China. Although most affected children have favorable clinical prognosis， some cases can escalate into severe MPP due to risk factors ...
YANG Kexin, PAN Li, ZENG Jinqing, LI Zhongke, LI Xufeng, ZHU Lingping, LIANG Ying, YANG Lifen, ZHANG Kun, DAI Min, CHEN Zhuanggui, LI Yating
doaj   +1 more source

Abnormal expression and clinical value analysis of long noncoding RNA cancer susceptibility candidate 2 in children with severe pneumonia complicated with respiratory failure

The Clinical Respiratory Journal, 2022
Objective Severe pneumonia occurs commonly in children and is the main cause of clinical infant mortality. This study tested the expression pattern of long noncoding RNA cancer susceptibility candidate 2 (CASC2) in the serum of children with severe ...
Jie Ni, Junfei Lu, Ding Lu
doaj   +1 more source

Expanded CURB-65: A new score system predicts severity of community-acquired pneumonia with superior efficiency [PDF]

, 2016
Aim of this study was to develop a new simpler and more effective severity score for communityacquired pneumonia (CAP) patients. A total of 1640 consecutive hospitalized CAP patients in Second Affiliated Hospital of Zhejiang University were included ...
Dong, Xiao Jun, Falcone, Marco, Farcomeni, Alessio, Liu, Jin Liang, Lu, Rui Qing, Luo, Shu Ya, Shi, Ling Xian, Venditti, Mario, Wu, Xue Jie, Xu, Feng, Zhao, Ying Li, Zhou, Hui   +11 more
core   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Machine learning for the prediction of severe pneumonia during posttransplant hospitalization in recipients of a deceased-donor kidney transplant.

Annals of Translational Medicine, 2020
Background Pneumonia accounts for the majority of infection-related deaths after kidney transplantation. We aimed to build a predictive model based on machine learning for severe pneumonia in recipients of deceased-donor transplants within the ...
You Luo, Zuofu Tang, Xiao Hu, Shuo Lu, B. Miao, Songlin Hong, Haiyun Bai, Chen Sun, J. Qiu, Huiying Liang, N. Na   +10 more
semanticscholar   +1 more source