Results 81 to 90 of about 652,669 (294)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study [PDF]

, 2017
Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory events in
Morice, Alyn, Morice, Alyn H., Morjaria, Jaymin, Morjaria, Jaymin B., Rigby, Alan   +4 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

The relationship between lactate dehydrogenase and Apolipoprotein A1 levels in patients with severe pneumonia [PDF]

Journal of Medical Biochemistry
Background: To investigate the relationship between lactate dehydrogenase and apolipoprotein A1 levels and the condition and prognosis of patients with severe pneumonia.
Wang Jiang, Wang Ronghua, Zhou Ying, Ma Yao, Xiong Chunyan   +4 more
doaj   +1 more source

Systemic infections after acute stroke [PDF]

, 2008
After an acute stroke, systemic infection can complicate the recovery process and lead to a worse clinical outcome, including a higher risk of mortality.
Damian Jenkinson, Englyst, Hamidon, Joseph Kwan, Kammersgaard, Kwan, Mike Vassallo, Nicola Englyst, Niel-Weise, Oconnor, V Hugh Perry, Werner   +11 more
core   +1 more source

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality [PDF]

, 2017
Background With the aim of populating the Lives Saved Tool (LiST) with parameters of effectiveness of existing interventions, we conducted a systematic review of the literature assessing the effect of Haemophilus influenzae type b (Hib) and pneumococcal (
Bhopal, Sunil, Boschi-Pinto, Cynthia, Campbell, Harry, Clark, Andrew, Jhass, Arnoupe, Johnson, Sue, Madhi, Shabir A., Rudan, Igor, Theodoratou, Evropi   +8 more
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis. [PDF]

, 2018
OBJECTIVES: A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and ...
Bowles, Kathryn H., Gaieski, David F., Harhay, Michael O., Meyer, Nathaniel, Mikkelsen, Mark E, Prescott, Hallie C., Small, Dylan S.   +6 more
core   +1 more source

Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus-Associated Pneumonia Among Children Aged <5 Years in the PERCH Study. [PDF]

, 2017
BACKGROUND.: Lack of a gold standard for identifying bacterial and viral etiologies of pneumonia has limited evaluation of C-reactive protein (CRP) for identifying bacterial pneumonia.
Awori, Juliet O, Baggett, Henry C, Baillie, Vicky L, Brooks, W Abdullah, Cascio, Stephanie, Chuananon, Somchai, Deloria Knoll, Maria, DeLuca, Andrea N, Driscoll, Amanda J, Ebruke, Bernard E, Endtz, Hubert P, Feikin, Daniel R, Hammitt, Laura L, Higdon, Melissa M, Howie, Stephen RC, Kaewpan, Anek, Kahn, Geoff, Karani, Angela, Karron, Ruth A, Kotloff, Karen L, Le, Tham, Levine, Orin S, Madhi, Shabir A, Moore, David P, Murdoch, David R, O'Brien, Katherine L, Park, Daniel E, PERCH Study Group, Prosperi, Christine, Rahman, Mohammed Ziaur, Salaudeen, Rasheed, Scott, J Anthony G, Seidenberg, Phil, Somwe, Somwe Wa, Sylla, Mamadou, Tapia, Milagritos D, Thea, Donald M, Zeger, Scott L   +37 more
core   +1 more source