Results 121 to 130 of about 177,712,728 (307)

Concordance of disease severity among family members with ankylosing spondylitis?

, 2004
Objective. The heritability of disease activity and function in ankylosing spondylitis (AS) have been estimated at 0.51 and 0.63 (i.e., 51% and 63%), respectively.
Hamersma, J, Hickey, S, Taylor, G, Taylor, G., Bradbury, L., Calin, A, Menon, A, Brophy, S., Brown, M. A., Menon, A., Brophy, S, Hickey, S., Bradbury, L, Brown, M, Hamersma, J., Calin, A.   +15 more
core  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Sever's disease complicated with osteomyelitis.

Acta clinica Croatica, 2014
Sever's disease is juvenile osteochondrosis of calcaneus, manifested with posterior heel pain and mild swelling, usually in young athletes, caused by repetitive microtrauma. The standard diagnostic procedures include radiographs and ultrasound examination. It is a self-limiting condition, usually treated conservatively.
Mustapić, Matej, Borić, Igor, Lepur, Dragan, Zadravec, Dijana, Višković, Klaudija   +4 more
openaire   +3 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework

The amyloid, tau, neurodegeneration (ATN) framework provides a biological staging model of Alzheimer's disease (AD) using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), or positron emission tomography (PET) biomarkers.
Corredor-Jerez, Ricardo, Maréchal, B., Démonet, Jean-François, Griffa, A., Griffa, Alessandra, Démonet, J.F., Ricchi, Ilaria, Ricchi, I., Rouaud, Olivier, Allali, Gilles, Maréchal, Bénédicte, Corredor-Jerez, R., Richiardi, J., Rouaud, O., Richiardi, Jonas, Allali, G.   +15 more
core   +1 more source

Distribution of disease severity ratings.

, 2014
Distribution of disease severity ratings.
Felicia Hawthorne (159364), Eric A. Evans (270085), Imran S. Haque (672585), Gabriel A. Lazarin (672582), Elizabeth A. Platt (672584), Nicholas S. Collins (672583)   +5 more
core   +1 more source

EMR Combined with CRB-65 Superior to CURB-65 in Predicting Mortality in Patients with Community-Acquired Pneumonia

Infection and Drug Resistance
Yi Sun,1,2 Hong Wang,3 Minghao Gu,4 Xingyu Zhang,5 Xiudi Han,1, Xuedong Liu,1 1Department of Respiratory and Critical Care Medicine, Qingdao Municipal Hospital Group, Qingdao, Shandong Province, 266000, People’s Republic of China; 2School of ...
Sun Y, Wang H, Gu M, Zhang X, Han X, Liu X   +5 more
doaj  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source