Results 111 to 120 of about 937,579 (305)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Are Albumin levels a good predictor of mortality in elderly patients with neck of femur fractures? [PDF]

, 2015
Neck of femur fractures are associated with significant morbidity and mortality. The National Hip Fracture database in England suggest an 8.2% 30 day mortality.
Harrison, S.J., Leeder, D.J., Sidhom, S.A., Stephenson, John   +3 more
core  

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Determinants of the choice of health care facility utilised by individuals in HIV/AIDS-affected households in the Free State province of South Africa [PDF]

This paper analyses differences in the choice of health care facility by individuals in HIV/AIDS-affected households in the Free State province of South Africa. Illness is more prevalent and severe amongst poorer affected households. The probability that
Frikkie Booysen, Martine Visser
core   +1 more source

Variables Predicting the Severity of a Mass Shooting: the connection to white supremacy [PDF]

, 2018
Since mass shootings have become increasingly relevant in today’s society, the subject of what makes a mass shooting deadly has become more and more popular.
Resnick, Sarina
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Perception of severity of the illness, information required, and anxiety among preoperative ENT patients in Songklanagarind Hospital

Journal of Health Science and Medical Research (JHSMR), 2008
This descriptive study aimed firstly to examine the perception of severity of the illness, the information required before an operation, and the anxiety level of the preoperative outpatients.
P Mesuwun, K Naka
doaj  

Impact of disease duration on functional status of patients with spinocerebellar ataxia type 2

Arquivos de Neuro-Psiquiatria
Objective: To correlate disease duration in spinocerebellar ataxia type 2 (SCA2) with disease severity, balance and functionality. Method: Sixteen SCA2 patients were analyzed for: disease duration, disease severity (SARA score), balance (Berg balance ...
Thiago R. Padilha Amarante, Sibele Y. M. Takeda, Hélio A. G. Teive, Marise Bueno Zonta   +3 more
doaj   +1 more source

Health Care Financing Reforms in Italy: Projects of Jefferson\u27s Center for Research in Medical Education and Health Care [PDF]

, 2005
No abstract ...
Cicchetti, Americo, Di Loreto, Paolo, Gonnella, Joseph S., Louis, Daniel Z., Manzoli, Lamberto, Rabinowitz, Carol, Taroni, Francesco, Yuen, Elaine J.   +7 more
core   +1 more source