Results 221 to 230 of about 957,939 (375)

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Heart rate variability displays 1/ f noise in critical illness and correlates with severity of multiple organ dysfunction

, 2000
SM Tibby, Helena Frndova, P. Cox
openalex   +1 more source

Increasing illness severity in very low birth weight infants over a 9-year period [PDF]

, 2006
David A. Paul, Kathleen H Leef, Robert Locke, Louis Bartoshesky, Judy Walrath, John L Stefano   +5 more
openalex   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

The case for an international severity of illness scoring system. [PDF]

Crit Care Sci
Tracy A, Salluh JIF, Buanes EA, Dongelmans DA, Finazzi S, Vijayaraghavan BKT, Lone N, Pilcher D, Reinikainen M, Sultan M, Thomson D, Waweru-Siika W, Haniffa R, Beane A.   +13 more
europepmc   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Mental Disorders in Medical Inpatients and the Association to Severity of Illness, Self-Rated Physical Disability, and Health Perception

, 2001
Morten Steen Hansen, Per Fink, Morten Frydenberg, Marie-Louise Oxhøj, Lene Søndergaard, Mette Brandt Eriksen   +5 more
openalex   +1 more source

The Severity of Acute Illness and Functional Trajectories in Hospitalized Older Medical Patients

The journals of gerontology. Series A, Biological sciences and medical sciences, 2017
F. Fimognari, A. Pierantozzi, W. De Alfieri, B. Salani, S. Zuccaro, Andrea Arone, Giacomo Palleschi, L. Palleschi   +7 more
semanticscholar   +1 more source

Aging as a Loss of Goal‐Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation

Advanced Science, EarlyView.
The paper proposes that the root cause of aging is the loss of anatomical goal‐directedness after development. Using evolutionary neural cellular automata simulations, the authors show that after the organism has reached its developmental homeostatic setpoint (the adult morphology), the absence of target state to pursue leads to a drifting anatomical ...
Léo Pio‐Lopez, Benedikt Hartl, Michael Levin   +2 more
wiley   +1 more source

The association between Oxford Acute Severity of Illness Score and mortality in critical hemorrhagic stroke patients: a retrospective cohort study. [PDF]

Sci Rep
Jiang Y, Qiu S, Peng Q, Huang L, Zhang L.   +4 more
europepmc   +1 more source