Impact of disease duration on functional status of patients with spinocerebellar ataxia type 2
Arquivos de Neuro-PsiquiatriaObjective: To correlate disease duration in spinocerebellar ataxia type 2 (SCA2) with disease severity, balance and functionality. Method: Sixteen SCA2 patients were analyzed for: disease duration, disease severity (SARA score), balance (Berg balance ...
Thiago R. Padilha Amarante +3 more
doaj +1 more source
Delta neutrophil index as an early marker of disease severity in critically ill patients with sepsis [PDF]
BMC Infectious Diseases, 2011 Abstract Background The immature granulocyte count has been reported to be a marker of infection and sepsis. The difference in leukocyte subfractions (delta neutrophil index, DNI) in ADVIA 2120 reflects the fraction of circulating immature granulocytes in the blood.
Kim Se +10 more
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Severity of illness-geriatric (SOI-G) : instrument development [PDF]
, 2002 Controlling for the wide variability in the physical health status of geriatric populations is important as severity of illness is known to both moderate and suppress relationships examined in psychosocial research.
Berg-Kolody, Lisa Dawn
core
Association between clinical frailty, illness severity and post-discharge survival: a prospective cohort study of older medical inpatients in Norway [PDF]
, 2021 Purpose Study associations between frailty, illness severity and post-discharge survival in older adults admitted to medical wards with acute clinical conditions.
Njaastad, Anne Mette +15 more
core +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Severity of illness at 24 and 48 hours.
, 2017 Severity of illness at 24 and 48 hours.
T. Eoin West (243067) +2 more
core +1 more source
A novel combined neutrophil-platelet score for diagnosing complicated appendicitis: a retrospective and prospective cohort study [PDF]
Acta Cirúrgica BrasileiraPurpose: We investigated the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) and combined them to create an inflammatory marker, the combined neutrophil-platelet score (CNPS), to serve as a diagnostic and predictive tool ...
Xiang Li +5 more
doaj +2 more sources
FEBS Open Bio, EarlyView.Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page +4 more
wiley +1 more source