Results 81 to 90 of about 465,142 (341)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Does culture matter at all in explaining why people still use traditional medicines? [PDF]

, 2012
Why do individuals still use traditional medicines when modern treatments are available? Economic explanations for an individual’s use of traditional instead of modern medicines are scarce and often fail to consider explanations beyond the conventional ...
Costa-i-Font, Joan, Sato, Azusa
core  

Psychological distress after stroke and aphasia: the first six months [PDF]

, 2010
Objective: We explored the factors that predicted psychological distress in the first six months post stroke in a sample including people with aphasia. Design: Prospective longitudinal observational study.
Ames, D., Chataway, J., Hilari, K., Marshall, J., Northcott, S., Roy, P., Wiggins, R. D.   +6 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Value of proteinuria in evaluating the severity of HELLP and its maternal and neonatal outcomes

BMC Pregnancy and Childbirth, 2023
Background HELLP syndrome refers to a group of clinical syndromes characterized by hemolysis, elevated liver enzymes and low platelet, and the evidence on the association between proteinuria and the severity of HELLP and its maternal and neonatal ...
Yan Jiao, Yan Liu, Hongyuan Li, Zimeng Song, Shiliang Wang, Jiao Zhang, Jian Li, Jia Liu, Peng Wang, Yanhong Chen   +9 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Discriminatory precision of renal angina index in prediction of acute kidney injury in children: a systematic review and meta-analysis

Archives of Academic Emergency Medicine, 2020
Introduction: There is still controversy over the value of renal angina index (RAI) in predicting acute renal failure (AKI) in children. Therefore, the present study aims to provide evidence by conducting a systematic review and meta-analysis on the ...
Arash Abbasi, Pardis Mehdipour Rabori, Ramtin Farajollahi, Kosar Mohammad Ali, Nematollah Ataei, Mahmoud Yousefifard, Mostafa Hosseini   +6 more
doaj   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Charlson Comorbidity Index and other predictors of in-hospital mortality among adults with community-acquired pneumonia [PDF]

Jornal Brasileiro de Pneumologia
Objective: To compare the performance of Charlson Comorbidity Index (CCI) with those of the mental Confusion, Urea, Respiratory rate, Blood pressure, and age = 65 years (CURB-65) score and the Pneumonia Severity Index (PSI) as predictors of all-cause in ...
Laura Fuchs Bahlis, Luciano Passamani Diogo, Sandra Costa Fuchs   +2 more
doaj   +4 more sources

Lower mortality rate in elderly patients with community-onset pneumonia on treatment with aspirin [PDF]

, 2015
BACKGROUND: Pneumonia is complicated by high rate of mortality and cardiovascular events (CVEs). The potential benefit of aspirin, which lowers platelet aggregation by inhibition of thromboxane A2 production, is still unclear. The aim of the study was to
Barilla', Francesco, Bertazzoni, Giuliano, Calvieri, Camilla, Cangemi, Roberto, Falcone, Marco, Farcomeni, Alessio, Palange, Paolo, Russo, Alessandro, Scarpellini, Maria Gabriella, Taliani, Gloria, Venditti, Mario, Violi, Francesco   +11 more
core   +1 more source