FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
REGRESSION-BASED PREDICTION OF ANXIETY SEVERITY [PDF]
Carpathian Journal of Electrical EngineeringThe present study explores the use of machine learning to predict self-reported anxiety levels based on demographic, behavioral, and physiological data.
Bogdan CHIS +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ranson′s criteria for acute pancreatitis in high altitude: Do they need to be modified?
The Saudi Journal of Gastroenterology, 2008 Background/Aim: To examine the validity of Ranson′s criteria in the prediction of the severity of acute pancreatitis (as judged by the occurrence of complications) in a high-altitude area of Saudi Arabia with a predominant biliary pancreatitis ...
Abu-Eshy Saeed +3 more
doaj
Analyzing Traffic Crash Severity With Combination of Information Entropy and Bayesian Network
IEEE Access, 2019 The analysis of severity causality for traffic crash is essential for enhancing the crash rescue responding speed, thereby reducing the casualties and property losses caused by roadway crashes.
Fang Zong +4 more
doaj +1 more source
Journal of Advanced Transportation, 2022 In the field of freeway traffic safety research, there is an increasing focus in studies on how to reduce the frequency and severity of traffic crashes.
Yang Yang +3 more
doaj +1 more source
Risk of postoperative acute kidney injury in patients undergoing orthopaedic surgery—development and validation of a risk score and effect of acute kidney injury on survival:observational cohort study [PDF]
, 2015 Funding: This study was funded by Tenovus Tayside, Chief Scientist Office, Scotland and a travelling fellowship from the Royal College of Physicians and Surgeons of Glasgow.
Bell, Samira +6 more
core +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Tomato leaf disease recognition based on multi-task distillation learning
Frontiers in Plant ScienceIntroductionTomato leaf diseases can cause major yield and quality losses. Computer vision techniques for automated disease recognition show promise but face challenges like symptom variations, limited labeled data, and model complexity.MethodsPrior ...
Bo Liu +11 more
doaj +1 more source