Results 151 to 160 of about 65,541 (293)

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo   +17 more
wiley   +1 more source

Similarity and dissimilarity in alterations of the gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane.

open access: yesPLoS ONE
Although sevoflurane is one of the most commonly used inhalational anesthetic agents, the popularity of desflurane is increasing to a level similar to that of sevoflurane.
Takehiro Nogi   +8 more
doaj   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

open access: yesAdvanced Science, Volume 13, Issue 6, 30 January 2026.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong   +5 more
wiley   +1 more source

Intermittent Fasting Alleviates Anesthesia/Surgery‐Induced Delirium‐Like Behavior in Aged Mice by Remodeling Gut Microbiota

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Preoperative intermittent fasting alleviates postoperative delirium‐like behaviors in aged mice by remodeling gut microbiota and preserving shortchain fatty acids. This gut‐brain interaction maintains hippocampal mitochondrial dynamics and synaptic plasticity, offering a promising non‐pharmacological strategy for perioperative neuroprotection. ABSTRACT
Peiying Huang   +9 more
wiley   +1 more source

Tregs Promote Astrocyte‐Neuron Lactate Shuttle via Inhibiting STING Pathway to Improve Neurological Recovery After Ischemic Stroke

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Tregs improve long‐term neurological recovery after ischemic stroke. Tregs promote ANLS and provide energy supply for neuronal remodeling after stroke. The mechanism underlying Tregs‐mediated ANLS enhancement involves suppression of the STING pathway.
Yao Meng   +16 more
wiley   +1 more source

Dysregulation of iron homeostasis and ferroptosis in sevoflurane and isoflurane associated perioperative neurocognitive disorders [PDF]

open access: gold
Mengrong Miao   +9 more
openalex   +1 more source

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