Results 161 to 170 of about 82,704 (334)

Loss of Glutaminase 1 in Small Sensory Neurons Prevents Nerve Injury Induced Mechanical Allodynia: Insights From Conditional Knockout Mice

open access: yesEuropean Journal of Pain, Volume 29, Issue 6, July 2025.
ABSTRACT Background Glutamate, the primary neurotransmitter released by nociceptors, is predominantly synthesised by the enzyme Glutaminase 1 (GLS1). The involvement of GLS1 in pain pathways is well supported, as Gls1 heterozygous mice exhibit altered nociception and GLS1 levels increase in the dorsal root ganglia (DRG) under chronic peripheral ...
Anabel Martínez‐Padilla   +4 more
wiley   +1 more source

Combined Effects of Intermittent Hypoxia and Amyloid Beta on Hippocampal Activity, Its Cholinergic Modulation, and Memory

open access: yesHippocampus, Volume 35, Issue 4, July 2025.
ABSTRACT Obstructive sleep apnea (OSA), characterized by repetitive upper airway obstruction, leads to chronic intermittent hypoxia (cIH) and induces cognitive and neuronal network disruptions similar to those observed in Alzheimer's disease (AD). These pathologies are often presented together in the elderly and share some pathophysiological mechanisms.
Laura Pinedo‐Vargas   +4 more
wiley   +1 more source

Serum and urinary inorganic fluoride levels after prolonged inhalation of sevoflurane in man [PDF]

open access: bronze, 1991
Yuta Kobayashi   +4 more
openalex   +1 more source

Morin Attenuates Diclofenac‐Induced Hepatocellular Death Injury via Nrf2/Ho‐1/NQO1, Beclin‐1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
ABSTRACT Diclofenac (DF), a nonsteroidal and anti‐inflammatory drug, has limited use due to its adverse effects on the liver. On the other hand, morin, a bioflavonoid, has biological and pharmacological properties. This study aims to investigate whether morin may protect against diclofenac‐induced liver toxicity.
Nurhan Akaras   +5 more
wiley   +1 more source

Relationship of arterial and exhaled CO2 during elevated artificial pneumoperitoneum pressure for introduction of the first trocar. [PDF]

open access: yes, 2011
The present study evaluated the correlation between arterial CO2 and exhaled CO2 during brief high-pressure pneumoperitoneum. Patients were randomly distributed into two groups: P12 group (n=30) received a maximum intraperitoneal pressure of 12mmHg ...
Afonso C. C. G. Machado   +11 more
core   +1 more source

Carvacrol Coadministration Ameliorates Lambda‐Cyhalothrin‐Induced Peripheral Neuropathy in Rats: Behavioral and Molecular Evidence

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
This study investigates the peripheral neuropathy induced by the pesticide Lambda‐cyhalothrin (CYH) and how carvacrol (CRV) treatment reduces these effects. CYH causes neurological disorders, oxidative stress, and inflammation, while CRV reverses these harmful effects with its antioxidant, anti‐inflammatory, and antiapoptotic properties.
Özge Kandemir   +6 more
wiley   +1 more source

An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesia

open access: yesFolia Neuropathologica
Sevoflurane is an inhalation anaesthetic agent widely used in clinical settings. Despite good surgical outcomes using sevoflurane, patients frequently develop postoperative cognitive dysfunction (POCD).
Wenfeng Gao   +5 more
doaj   +1 more source

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