Results 231 to 240 of about 60,245 (274)

A Neural Circuit from the Paraventricular Thalamus to the Bed Nucleus of the Stria Terminalis for the Regulation of States of Consciousness during Sevoflurane Anesthesia in Mice

Anesthesiology, 2022
Background: The neural circuitry underlying sevoflurane-induced modulation of consciousness is poorly understood. This study hypothesized that the paraventricular thalamus bed nucleus of the stria terminalis pathway plays an important role in regulating ...
Jia-Yan Li, Shao-Jie Gao, Ran Li, Wei Wang, Jia Sun, Longxin Zhang, Jiayi Wu, Dai-Qiang Liu, Pei Zhang, B. Tian, W. Mei   +10 more
semanticscholar   +1 more source

Anesthesia and the Developing Brain: A Review of Sevoflurane-induced Neurotoxicity in Pediatric Populations.

Clinical Therapeutics, 2021
PURPOSE For over 150 years of anesthetic practice, it was believed that the effects of general anesthetics were temporary and not adverse. A growing number of studies over the past 2 decades, however, have identified structural and cognitive ...
Carol Apai, R. Shah, Khoa Tran, Shridevi Pandya Shah   +3 more
semanticscholar   +1 more source

Participation of Mind Bomb-2 in Sevoflurane Anesthesia Induces Cognitive Impairment in Aged Mice via Modulating Ferroptosis.

ACS Chemical Neuroscience, 2021
Postoperative cognitive dysfunction (POCD) is a complication of the central nervous system (CNS) often occurred after surgery or anesthesia in the elder patients. Mind bomb-2 (MIB2) has been reported to modulate neuronal functions.
Lili Zhao, Haixia Gong, Haijin Huang, Gulisitan Tuerhong, Hai-mei Xia   +4 more
semanticscholar   +1 more source

Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice.

Journal of Nutritional Biochemistry, 2020
Sevoflurane, the most commonly used inhaled anesthetics in pediatric anesthesia, has been reported to induce cognitive impairment in developing brain in preclinical and clinical settings.
Xiaole Tang, Xuan Wang, G. Fang, Yi Zhao, Jing Yan, Zhi-qiang Zhou, R. Sun, A. Luo, S. Li   +8 more
semanticscholar   +1 more source

Breakthrough analysis of continuous fixed-bed adsorption of sevoflurane using activated carbons.

Chemosphere, 2020
The inhalational anaesthetic agent - sevoflurane is widely employed for the induction and maintenance of surgical anaesthesia. Sevoflurane possesses a high global warming potential that imposes negative impact to the environment.
T. N. Ang, B. Young, M. Taylor, R. Burrell, M. Aroua, S. Baroutian   +5 more
semanticscholar   +1 more source

Survival after primary breast cancer surgery following propofol or sevoflurane general anesthesia—A retrospective, multicenter, database analysis of 6305 Swedish patients

Acta Anaesthesiologica Scandinavica, 2020
Retrospective studies indicate that the choice of anesthetic can affect long‐term cancer survival. Propofol seems to have an advantage over sevoflurane. However, this is questioned for breast cancer.
M. Enlund, Anders Berglund, R. Ahlstrand, J. Walldén, J. Lundberg, Fredrik Wärnberg, Andreas Ekman, Nina Sjöblom Widfeldt, Anna Enlund, L. Bergkvist   +9 more
semanticscholar   +1 more source

TOXICITY OF SEVOFLURANE IN RATS

Anesthesia & Analgesia, 1987
Sevoflurane, an experimental potent volatile anesthetic with a low blood/gas partition coefficient, degrades in the presence of soda lime to products the toxicity of which is unknown. We tested whether toxic products were produced by the passage of sevoflurane through soda lime, and a comparison was made of the toxicity of sevoflurane passed through ...
D P, Strum, E I, Eger, B H, Johnson, E P, Steffey, L D, Ferrell   +4 more
openaire   +2 more sources

Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor.

Neuroscience Letters, 2020
Postoperative cognitive dysfunction in elderly patients has been related to neurodegenerative disorders and mortality. Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity. Given the advantages of using
Zhe Xu, Bin Qian
semanticscholar   +1 more source

Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis.

Toxicology Letters, 2020
Sevoflurane is commonly used in clinical anesthesia. However, some reports indicated that Sevoflurane could induce mitochondrial injury and neuroapoptosis.
Xiaoqiu Zhu, Yiyi Yao, M. Guo, Jin Li, Pengfeng Yang, Hui Xu, D. Lin   +6 more
semanticscholar   +1 more source

Biotransformation of Sevoflurane

Anesthesia & Analgesia, 1995
Several characteristics of sevoflurane biotransformation are apparent from the preceding investigations. Metabolism is rapid, with fluoride and HFIP appearing in plasma within minutes after the start of sevoflurane administration (38-40,51). Peak plasma fluoride concentrations generally occur within approximately 1 h after the termination of ...
openaire   +2 more sources