Results 41 to 50 of about 4,114,102 (347)

Infection Models for Pine Wilt Disease on the Basis of Vector Behaviors

Population Ecology, EarlyView.
Infection models for pine wilt disease without vector density were built to estimate the transmission coefficient of the pathogenic nematode. The models successfully simulated the annual change in the density of infected trees for four pine stands. ABSTRACT Pine wilt disease is caused by the pinewood nematode (Bursaphelenchus xylophilus Steiner et ...
Katsumi Togashi
wiley   +1 more source

Sex and gender correlates of sexually polymorphic cognition

Biology of Sex Differences
Background Sexually polymorphic cognition (SPC) results from the interaction between biological (birth-assigned sex (BAS), sex hormones) and socio-cultural (gender identity, gender roles, sexual orientation) factors.
Louis Cartier, Mina Guérin, Fanny Saulnier, Ioana Cotocea, Amine Mohammedi, Fadila Moussaoui, Sarah Kheloui, Robert-Paul Juster   +7 more
doaj   +1 more source

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

Endocrine reviews, 2016
The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along with mounting evidence of clinically important sex and gender differences.
A. Kautzky-Willer, J. Harreiter, G. Pacini   +2 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Case Report: Prenatal Genetic Counseling to Parents of Fetuses Suspected of Having Ambiguous Genitalia

Frontiers in Pediatrics, 2021
The occurrence of fetuses suspected of having ambiguous genitalia will likely increase in the future. Currently, the impact of prenatal genetic counseling on parents' understanding and psychological preparedness has not been addressed.
Takeshi Sato, Takeshi Sato, Tomohiro Ishii, Tomohiro Ishii, Yu Yamaguchi, Yosuke Ichihashi, Yosuke Ichihashi, Daigo Ochiai, Hiroshi Asanuma, Hiroshi Asanuma, Tatsuo Kuroda, Tatsuo Kuroda, Tomonobu Hasegawa, Tomonobu Hasegawa   +13 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Individuals under voluntary treatment with sexual interest in minors: what risk do they pose?

Frontiers in Psychiatry, 2023
Child Sexual Abuse (CSA) and the production, use, and distribution of Child Sexual Abuse Material (CSAM) are key threats to children’s mental health. From the perspective of indicated prevention, it can be assumed that some persons with a sexual interest
Fritjof von Franqué, Ralf Bergner-Koether, Ralf Bergner-Koether, Stefanie Schmidt, Jan S. Pellowski, Jan H. Peters, Göran Hajak, Peer Briken   +7 more
doaj   +1 more source

Sex and Gender and Sex

Mare Nostrum, 2020
This article challenges some of the prevailing notions pertaining to non-binary sex and fluid gender in modern academia. Beginning with a look at the history of the sex vs. gender debate, it turns to the study of genetics to determine how binary sex is, overturning many current beliefs about the biological bases of multiple sexes.
openaire   +2 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

A role for TRPC3 in mammalian testis development

Frontiers in Cell and Developmental Biology
SOX9 is a key transcription factor for testis determination and development. Mutations in and around the SOX9 gene contribute to Differences/Disorders of Sex Development (DSD).
Zhenhua Ming, Zhenhua Ming, Stefan Bagheri-Fam, Emily R. Frost, Janelle M. Ryan, Janelle M. Ryan, Brittany Vining, Brittany Vining, Vincent R. Harley, Vincent R. Harley   +9 more
doaj   +1 more source