Results 161 to 170 of about 60,046 (266)

The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review. [PDF]

Epigenetics Chromatin
Letchumanan P, Theva Das K.
europepmc   +1 more source

Season of birth and variations in male reproductive health: A population‐based cohort study

Andrology, EarlyView.
Abstract Background Season of birth has been associated with various later reproductive health outcomes in women, but little is known on the potential associations in men. Objectives To investigate the association between season of birth and semen characteristics, testes volume and reproductive hormone levels in young men.
Anne Gaml‐Sørensen, Nis Brix, Sandra Søgaard Tøttenborg, Karin Sørig Hougaard, Siri Eldevik Håberg, Mikko Myrskylä, Gunnar Toft, Jens Peter Ellekilde Bonde, Cecilia Høst Ramlau‐Hansen   +8 more
wiley   +1 more source

DNA Methylation Dynamics Reflect Sex and Status Differences in Mortality Rates in a Polygynous Bat. [PDF]

Mol Ecol
Adams DM, Rayner JG, Hex SBSW, Wilkinson GS.   +3 more
europepmc   +1 more source

The IKZF1 N159S mutation is associated with poor outcome and a distinct molecular profile in adult patients with AML

British Journal of Haematology, EarlyView.
Summary IKZF1 mutations are recurrent alterations in acute myeloid leukaemia (AML), and hotspot point mutation, N159S, has recently been associated with unique gene expression and adverse risk. To better understand the molecular and clinical associations of IKZF1 N159S‐mutated AML, we performed a pooled analysis of 4136 AML patients.
Sebastian Stasik, Jan‐Niklas Eckardt, Christoph Röllig, Claudia D. Baldus, Uwe Platzbecker, Hubert Serve, Carsten Müller‐Tidow, Kerstin Schäfer‐Eckart, Martin Kaufmann, Stefan W. Krause, Tim Sauer, Mathias Hänel, Andreas Neubauer, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Christian Thiede, on behalf of the Study Alliance Leukemia (SAL)   +18 more
wiley   +1 more source

HDI-STARR-seq: Condition-specific enhancer discovery in mouse liver in vivo. [PDF]

BMC Genomics
Chang TY, Waxman DJ.
europepmc   +1 more source

NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex development. [PDF]

Nat Commun
Estermann MA, Grimm SA, Kitakule AS, Rodriguez KF, Brown PR, McClelland K, Amato CM, Yao HH.   +7 more
europepmc   +1 more source

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Gene regulation is frequently altered in diseases in unique and patient‐specific ways. Hence, personalised strategies have been proposed to infer patient‐specific gene‐regulatory networks. However, existing methods do not scale well because they often require recomputing the entire network per sample.
Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List   +5 more
wiley   +1 more source

Assessment of Patients With Beta‐Lactams Positive Provocation Tests by Biomarkers of IgG‐Related Neutrophil Activation

Clinical &Experimental Allergy, EarlyView.
Neutrophil activation in beta‐lactams (BL) immediate hypersensitivity reactions (IHR). Factor component analysis of IHR biomarkers suggests an IgG‐mediated mechanism. We propose Neutrophil Elastase as a biomarker of neutrophil activation in BL IHR. ABSTRACT Background Beta‐lactams (BLs) are the predominant cause of immediate allergic reactions to drugs.
Adrienne Astrid Gallizzi, Rosa‐Maria Guéant‐Rodriguez, Cosmin Boteanu, Jean‐Marc Alberto, Cécile Lakomy, Huguette Louis, Celine Chery, Pauline Renard, Véronique Regnault, Ramia Safar, Almut Heinken, Antonino Romano, Jose‐Julio Laguna, Jean‐Louis Guéant   +13 more
wiley   +1 more source

Sex chromatin and nuclear sex-specific appendages in the newborn

The Turkish Journal of Pediatrics, 1969
S Sakhaullah
doaj  

Testis‐Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis

Cell Proliferation, EarlyView.
PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang, Kailun Fang, Yongliang Shang, Xu Zhou, Qiqi Shao, Si Li, Ping Wang, Charlie Degui Chen, Liangran Zhang, Shunxin Wang   +9 more
wiley   +1 more source