Results 181 to 190 of about 123,835 (338)

Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease‐Like Brain Transcriptomic Signatures in AppNL‐G‐F Mice

Aging Cell, EarlyView.
Choline‐protected genes correlated with clinical dementia rating, inflammation, and tauopathy in human AD samples, suggesting that adequate choline intake could be a preventive strategy for Alzheimer's disease (AD). ABSTRACT Alzheimer's disease (AD)—the leading cause of dementia—has no cure, inadequate treatment options, and a limited understanding of ...
Thomas A. Bellio, Andre Krunic, Mary S. Campion, Rohan Dupaguntla, Adam Labadorf, Thor D. Stein, Honghuang Lin, Tiffany J. Mellott, Jan K. Blusztajn   +8 more
wiley   +1 more source

Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts. [PDF]

Nat Genet
Liu Q, Jiang F, Li R, Liu S, Fang W, Li X, Hu T, Feng L, Zhang J, Liu Z, He J, Guo W, Wang X, Sun Z, Li J, Gao Y, Yi J, Li Q, Wang X, Wei L, Kang L.   +20 more
europepmc   +1 more source

SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression. [PDF]

FEBS J, 2014
Comptour A, Moretti C, Serrentino ME, Auer J, Ialy-Radio C, Ward MA, Touré A, Vaiman D, Cocquet J.   +8 more
europepmc   +1 more source

Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns

Aging Cell, EarlyView.
Intestinal stem cells occur in clusters, and the cycle time of stem cells increases with age. The age‐dependent decline in structural intestinal tissue homeostasis is associated with a decline in stem cell activity. Aging causes significant changes in intestinal gene expression; intermittent fasting from adulthood onwards results in a gene expression ...
Michael Kothmayer, Sylvia Laffer, Philipp Widmayer, Elmar E. Ebner, Fehima Ugarak, David Martin, Stefan H. Geyer, Kareem Elsayad, Wolfgang J. Weninger, Sabine Lagger, Klara Weipoltshammer, Oliver Pusch, Christian Schöfer   +12 more
wiley   +1 more source

Extensive differential gene expression and regulation by sex in human skeletal muscle. [PDF]

Cell Genom
Hanks SC, Mauger AS, Varshney A, Ciotlos DL, Manickam N, Narisu N, Shumway AJ, Orchard P, Erdos MR, Sweeney MD, Okamoto J, Jackson AU, Stringham HM, Bonnycastle LL, Zhou X, Lakka TA, Mohlke KL, Tuomilehto J, Laakso M, Boehnke M, Sethupathy P, Collins FS, Koistinen HA, Parker SCJ, Scott LJ.   +24 more
europepmc   +1 more source

Epigenetic Applications in Adverse Outcome Pathways and Chemical Risk Evaluation [PDF]

, 2017
Allard, P, Angrish, M, Chadwick, LH, Chorley, BN, Hines, E, McCullough, SD   +5 more
core  

Age‐Associated Transcriptomic and Epigenetic Alterations in Mouse Hippocampus

Aging Cell, EarlyView.
Single‐nucleus multiome sequencing of hippocampus reveals aging‐dependent changes in gene expression and chromatin accessibility. Chromatin alterations in synaptic genes often occur without corresponding expression changes, suggesting a “susceptible” chromatin state.
Merve Bilgic, Rinka Obata, Vlada‐Iuliana Panfil, Ziying Zhu, Mai Saeki, Yukiko Gotoh, Yusuke Kishi   +6 more
wiley   +1 more source

Editorial: Regulatory mechanisms of gene expression, chromatin structure and nuclear dynamics in gametogenesis

Frontiers in Cell and Developmental Biology, 2022
Soichiro Yamanaka, Satoshi H. Namekawa, Kei-ichiro Ishiguro   +2 more
doaj   +1 more source

Mechanisms and etiology of male health disorders: hormones, cancer, and fertility. [PDF]

Cell Commun Signal
Cordani M, Ambrosini G, Dando I, González-Menéndez P.   +3 more
europepmc   +1 more source

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice

Aging Cell, EarlyView.
Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration. ABSTRACT Adult resident stem cells are capable of regenerating tissues that manifest signs of “rejuvenation” in flatworms and mice of older ages.
Kevin A. Murach, Cory M. Dungan, Toby L. Chambers, Steve Horvath, Jayakrishnan Nandakumar, Vadim N. Gladyshev, Scott D. Pletcher, Xiaoting Dai, Longhua Guo   +8 more
wiley   +1 more source