Results 211 to 220 of about 128,998 (343)

A male-transmitted B chromosome undergoes strong meiotic drag in females of the jewel wasp Nasonia vitripennis. [PDF]

PLoS Biol
Ferree PM, Cummings J, Garman E, Solomon J, Martinez KS.   +4 more
europepmc   +1 more source

Comparative Analysis of Chromatin Binding by Sex Comb on Midleg (SCM) and Other Polycomb Group Repressors at a Drosophila Hox Gene

, 2010
Liangjun Wang, Neal Jahren, Ellen Miller, Carrie S. Ketel, Daniel R. Mallin, Jeffrey A. Simon   +5 more
openalex   +1 more source

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Gene regulation is frequently altered in diseases in unique and patient‐specific ways. Hence, personalised strategies have been proposed to infer patient‐specific gene‐regulatory networks. However, existing methods do not scale well because they often require recomputing the entire network per sample.
Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List   +5 more
wiley   +1 more source

HSF5: A novel switch for meiotic pachynema progression in male germ cells. [PDF]

Genes Dis
Luo C, Yu Z, Liu D, Xu H, Zhan J, Sun F.
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Testis-specific protein HSF5 is essential for proper chromatin organization and transcriptional reprogramming to drive pachynema progression. [PDF]

Zool Res
Luo CH, Fan ZW, Yu ZQ, Liu DL, Xu HR, Zhou SM, Zhu XJ, Liu HC, Shao LF, Li ZA, Xie C, Zhan JF, Sun F.   +12 more
europepmc   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Chromatin Profiling Reveals Distinct Male and Female Trajectories for Developmental Learning Potential. [PDF]

Dev Neurobiol
Kunzelman GW, Batistuzzo A, London SE.
europepmc   +1 more source

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

Cancer Science, EarlyView.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang, Ziwei Fu, Chuan Xiong, Jing Zhang, Qiang Luo   +4 more
wiley   +1 more source

Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer's disease App^NL-G-F knock-in mouse model. [PDF]

Sci Rep
Okhovat M, Layman CE, Davis BA, Pederson A, O'Niel A, Holden S, Kessler K, Acharya SN, Wheeler KJ, Nevonen KA, Herrera J, Ward S, Vigh-Conrad K, Adey A, Raber J, Carbone L.   +15 more
europepmc   +1 more source