Results 271 to 280 of about 1,768,588 (357)

Effects of AZFc (b2/b4, b1/b3, b2/b3, and gr/gr) deletions and primary duplications on the outcomes of the first intracytoplasmic sperm injection treatment cycle: A single‐center retrospective cohort study

Andrology, EarlyView.
Abstract Background Current advances in high‐throughput sequencing technology enable the precise identification of Y chromosome microdeletion and primary duplication in infertile couples, but the mechanism and clinical significance of these mutations in assisted reproductive techniques remain unclear.
Linlin Li, Xiangyin Liu, Xinying Wang, Hongguo Zhang, Ruizhi Liu   +4 more
wiley   +1 more source

Genome-wide associations with metabolic syndrome among UK Biobank participants reporting use of second-generation antipsychotics. [PDF]

Pharmacotherapy
Rouby NE, Owusu-Obeng A, Preuss M, Lee S, Shi M, Lape M, Martin LJ, Namjou-Khales B, Kottyan LC, Van Driest SL, Mosley JD, DelBello MP.   +11 more
europepmc   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Genomic diversity in functionally relevant genes modifies neurodevelopmental versus neoplastic risks in individuals with germline PTEN variants. [PDF]

NPJ Genom Med
Kim AY, Yehia L, Eng C.
europepmc   +1 more source

Fetal exposure to a mixture of endocrine‐disrupting chemicals and biomarkers of male fecundity: A population‐based cohort study

Andrology, EarlyView.
Abstract Background Fetal exposure to endocrine‐disrupting chemicals (EDCs) has been associated with reduced male fecundity, but with few studies considering chemical mixtures. Objectives We assessed the association between fetal exposure to a mixture of EDCs and biomarkers of male fecundity in young adulthood.
Sidsel Dan Hull, Karin Sørig Hougaard, Gunnar Toft, Kajsa Kirstine Ugelvig Petersen, Esben Meulengracht Flachs, Christian Lindh, Cecilia Høst Ramlau‐Hansen, Lauren A. Wise, Allen Wilcox, Zeyan Liew, Jens Peter Bonde, Sandra Søgaard Tøttenborg   +11 more
wiley   +1 more source

Rare damaging variants in the sex differences of congenital heart disease: an exome sequencing study. [PDF]

EBioMedicine
Sun H, Hao X, Liu H, Zhang S, Han J, Zhang Y, Liu T, Yang X, Wang H, Fan J, Guan Y, Peng N, Xie J, Xia H, Ji X, Xu Y, Zhang J, Wang J, Lan F, Zhang H, Gu X, He Y.   +21 more
europepmc   +1 more source

Gonadal function in males with WFS1 spectrum disorder (Wolfram syndrome)—A European cohort perspective

Andrology, EarlyView.
Abstract Background WFS1 spectrum disorder, also known as Wolfram syndrome (WS) is an ultra‐rare (<1:500,000; ORPHA: 3463) monogenic (OMIM #222300) progressive neuroendocrine and neurodegenerative disorder, characterised by early‐onset insulin‐dependent diabetes, optic atrophy, central diabetes insipidus and sensi‐neuronal deafness.
Julia Rohayem, Olivia Cunningham, Denise Williams, Joachim Wistuba, Liam McCarthy, Timothy G. Barrett, Renuka P. Dias   +6 more
wiley   +1 more source

Epigenetic Consequences of In Utero PFAS Exposure: Implications for Development and Long-Term Health. [PDF]

Int J Environ Res Public Health
Abdulkadir A, Kandel S, Lewis N, D'Auvergne O, Rosby R, Hossain E.   +5 more
europepmc   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

The Inactive X Chromosome: A Genetic Driver of Female-Biased Rheumatic Autoimmune Disorders? [PDF]

Eur J Immunol
Ferrayé L, Nieucel M, Savignac M, Chaumeil J, Guéry JC.   +4 more
europepmc   +1 more source