British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Gene regulation is frequently altered in diseases in unique and patient‐specific ways. Hence, personalised strategies have been proposed to infer patient‐specific gene‐regulatory networks. However, existing methods do not scale well because they often require recomputing the entire network per sample.
Johannes Kersting +5 more
wiley +1 more source
Epigenetic liquid biopsies reveal endothelial turnover and erythropoiesis in asymptomatic COVID-19. [PDF]
Life Sci AllianceBen-Ami R +27 more
europepmc +1 more source
Reversibility of sex changes in the plant kingdom: more important than we thought?
Biological Reviews, EarlyView.ABSTRACT Compared to animals, plants show a wide range of reproductive strategies with different degrees of sex separation (e.g. dioecy, monoecy, hermaphroditism). While sex expression was previously thought to be genetically determined and fixed in plants, accumulating evidence suggests that sex expression can change reversibly even within one ...
Iris Sammarco +3 more
wiley +1 more source
Chromosome and sex-chromatin studies of patients with hypospadias
The Turkish Journal of Pediatrics, 1969 E Tunçbilek
doaj
Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata. [PDF]
Front ImmunolGay-Mimbrera J +12 more
europepmc +1 more source
Clinical &Experimental Allergy, EarlyView.Neutrophil activation in beta‐lactams (BL) immediate hypersensitivity reactions (IHR). Factor component analysis of IHR biomarkers suggests an IgG‐mediated mechanism. We propose Neutrophil Elastase as a biomarker of neutrophil activation in BL IHR. ABSTRACT Background Beta‐lactams (BLs) are the predominant cause of immediate allergic reactions to drugs.
Adrienne Astrid Gallizzi +13 more
wiley +1 more source
Androgen-induced AR-BRD4 transcriptional regulatory complex promotes malignant proliferation of osteosarcoma cells. [PDF]
Cell Death DiscovTian JM, Dong YH, Li Z, Zhou Y, Huang J.
europepmc +1 more source
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, EarlyView.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-derived Suppressor Cells
Angel Charles +11 more
openalex +1 more source
Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation. [PDF]
Front Cell Dev BiolMarín-Gual L +6 more
europepmc +1 more source