Results 41 to 50 of about 123,835 (338)

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. [PDF]

, 2018
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative ...
Abecasis, Goncalo, Alver, Maris, Bloom, Jonathan M, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Engreitz, Jesse M, Ernst, Jason, Esko, Tonu, Ganna, Andrea, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Khera, Amit V, Lander, Eric S, Manichaikul, Ani, Mitchell, Braxton, Montasser, May, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, O'Connell, Jeffrey R, Peloso, Gina M, Perry, James A, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni E, Salomaa, Veikko, Seed, Cotton, Surakka, Ida L, Vasan, Ramachandran S, Willer, Cristen J, Wilson, James G, Zekavat, Seyedeh Maryam, Zhou, Wei   +36 more
core   +2 more sources

Genetic determinants of co-accessible chromatin regions in activated T cells across humans. [PDF]

, 2018
Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease.
A Barrie, A Battle, A Franke, AA Shabalin, AM Klein, AR Quinlan, Atsede Siba, Aviv Regev, Aviva P. Aiden, B Li, BE Stranger, C Hou, Christine S. Cheng, Christophe Benoist, Chun J. Ye, CJ Ye, CK Stroud, D Hnisz, D Lee, D Sakata, DE Speiser, Dmytro Lituiev, E Elinav, E Splinter, EM Schmidt, Erez Lieberman Aiden, EZ Macosko, G Jun, G McVicker, H Kilpinen, H Li, H Li, HK Finucane, HM Kang, Howard Y. Chang, Ido Machol, Ivo Wortman, J Yang, JD Buenrostro, JD Buenrostro, JD Storey, JE Phillips, JF Degner, JN Hirschhorn, JS Delisle, K Enjyoji, Kendrick L. Hougen, KK Farh, L Chen, L Plesner, M Feuerer, M Ghandi, M Kasowski, M Kronenberg, M Kurachi, M. Grace Gordon, Marcin Tabaka, MB Gerstein, Meena Subramaniam, MI Love, MI McCarthy, Michael A. Beer, MN Lee, MT Maurano, Muhammad Shamim, MY Donath, N Kumasaka, NC Durand, Neva C. Durand, NP Restifo, P Cauchy, P Li, PC Hollenhorst, Philip L. De Jager, PM Visscher, PS Ohashi, R Satija, Rachel E. Gate, RE Thurman, RM Samstein, Roadmap Epigenomics Consortium,, S Deaglio, S Heinz, S Neph, SM Waszak, SS Rao, Su-Chen Huang, T Lappalainen, T Raj, The ENCODE Project Consortium., Ting Feng, TL Murphy, UM Marigorta, WA Whyte, WJ Astle, X Chen, X Sun, Y Belkaid, Y Zhang, YY Fan   +99 more
core   +2 more sources

Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.

PLoS Genetics, 2023
The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid ...
Ana Catalán, Justin Merondun, Ulrich Knief, Jochen B W Wolf   +3 more
doaj   +1 more source

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo [PDF]

, 2014
Here, we exploit the spatial separation of temporal events of neural differentiation in the elongating chick body axis to provide the first analysis of transcriptome change in progressively more differentiated neural cell populations in vivo.
Abranches, Akai, Altschul, Amijee, Arbeitman, Aubert, Bel-Vialar, Benjamini, Bradford, Brown, Chitnis, Delfino-Machín, Deschamps, Deschenes, Diez del Corral, Diez del Corral, Dittmar, Eblaghie, Fior, Goodwin, Hamburger, Henrique, Irizarry, Jares, Kuhns, Landeira, Lessard, Li, Lobjois, Lunn, Martin, Miettinen, Minowada, Mitiku, Olivera-Martinez, Ozbudak, Ozsolak, Park, Patel, Perry, Rae, Rae, Schurch, Smyth, Smyth, Stavridis, Stern, Storey, Sultan, Tsakiridis, Tzouanacou, van der Vlag, Wilcock, Willnow, Wilson, Wu, Zhang, Zhao   +57 more
core   +5 more sources

ATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken

Epigenetics & Chromatin, 2023
Background Sex determination and differentiation are complex and delicate processes. In female chickens, the process of sex differentiation is sensitive and prone to be affected by the administration of aromatase inhibitors, which result in chicken sex ...
Xiuan Zhang, Jianbo Li, Xiqiong Wang, Yuchen Jie, Congjiao Sun, Jiangxia Zheng, Junying Li, Ning Yang, Sirui Chen   +8 more
doaj   +1 more source

Sex Chromatin and Nuclear Sexing in Birds

CYTOLOGIA, 1970
The present study deals with the incidence and distribution of sex chromatin body, drumstick and sessile bodies in two pairs, each of Gallus domesticus, Columba livia and Passer domesticus. Somatic tissues, i.e. liver, duodenum, skin and blood from both sexes were examined.
Chaman Lal Arora, M. Dharamarajan, M. Dharamarajan   +2 more
openaire   +4 more sources

Chromosome complement and meiosis in three species of the Neotropical bug genus Antiteuchus (Heteroptera, Pentatomidae, Discocephalinae) [PDF]

, 2006
Orcein staining of spermatocytes was used to study the meiotic behavior of holocentric chromosomes in three member of the genus Antiteuchus (commonly known as stink bugs). We describe and illustrate the karyotype of Antiteuchus mixtus, A. sepulcralis and
de Souza, Maria José, Lanzone, Cecilia
core   +2 more sources

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]

, 2020
Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders.
Beleggia, Filippo, Bustos, Matias A., Checa Rodríguez, Cintia, Goergens, Jonas, Huertas Sánchez, Pablo, Isensee, Jörg, Jachimowicz, Ron D., Velpula, Bhagya Bhavana   +7 more
core   +1 more source

Sex Determination by Observation of Barr Body in Teeth Subjected to High Temperatures [PDF]

, 2011
Galdames, IS (reprint author), Univ Talca, Ave Lircay S-N Oficina 104, Valparaiso, Chile.Sex determination is one of the keys in the identification process.
Cantin, M., Flores, A., Galdames, I.S., Roa, I., Zavando, D.   +4 more
core   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources