Results 41 to 50 of about 60,046 (266)
IJU Case Reports, Volume 6, Issue 1, Page 81-84, January 2023., 2023 Introduction Small‐cell carcinoma of the urinary bladder has a poor prognosis, and no standard treatment has been established. We encountered a case of a patient with metastasis in which complete response and long‐term survival were obtained by treating the primary lesion with a combination of irinotecan, carboplatin chemotherapy, and radiation therapy.
Shinya Miyazaki +4 more
wiley +1 more source
The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.
PLoS Biology, 2009 Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR).
Julie Cocquet +6 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Klinefelter syndrome (KS, 47XXY) is a disorder characterized by sex chromosomal aneuploidy, which may lead to changes in epigenetic regulations of gene expression. To define epigenetic architectures in 47XXY, we annotated DNA methylation in euploid males
Nan Miao +8 more
doaj +1 more source
Adaptive elastic properties of chromatin fiber [PDF]
, 2002 Chromatin is a complex of DNA and specific proteins forming an intermediary level of organization of eukaryotic genomes, between double-stranded DNA and chromosome. Within a generic modeling of the chromatin assembly, we investigate the interplay between the mechanical properties of the chromatin fiber and its biological functions.
arxiv +1 more source
Model chromatin flows: numerical analysis of linear and nonlinear hydrodynamics inside a sphere [PDF]
arXiv, 2023 We solve a hydrodynamic model of active chromatin dynamics, within a confined geometry simulating the cell nucleus. Using both analytical and numerical methods, we describe the behavior of the chromatin polymer driven by the activity of motors having polar symmetry, both in the linear response regime as well as in the long-term, fully nonlinear regime ...
arxiv
Journal of Applied Toxicology, Volume 43, Issue 1, Page 22-31, January 2023., 2023 Abstract Titanium dioxide (TiO2) is used extensively as a white pigment in the food industry, personal care, and a variety of products of everyday use. Although TiO2 has been categorized as a bioinert material, recent evidence has demonstrated different toxicity profiles of TiO2 nanoparticles (NPs) and a potential health risk to humans.
Vida Mohammadparast, Beth L. Mallard
wiley +1 more source
The Drosophila CLAMP protein associates with diverse proteins on chromatin. [PDF]
PLoS ONE, 2017 Gaining new insights into gene regulation involves an in-depth understanding of protein-protein interactions on chromatin. A powerful model for studying mechanisms of gene regulation is dosage compensation, a process that targets the X-chromosome to ...
Jennifer A Urban +3 more
doaj +1 more source
Dual mechanism of chromatin remodeling in the common shrew sex trivalent (XY 1Y 2)
Comparative Cytogenetics, 2017 Here we focus on the XY1Y2 condition in male common shrew Sorex araneus Linnaeus, 1758, applying electron microscopy and immunocytochemistry for a comprehensive analysis of structure, synapsis and behaviour of the sex trivalent in pachytene spermatocytes.
Sergey N. Matveevsky +4 more
doaj +3 more sources
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
HU308 Mitigates Osteoarthritis by Stimulating Sox9‐Related Networks of Carbohydrate Metabolism
Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 154-170, January 2023., 2023 ABSTRACT Osteoarthritis (OA) is characterized by progressive, irreversible erosion of articular cartilage accompanied by severe pain and immobility. This study aimed to assess the effect and mechanism of action of HU308, a selective cannabinoid receptor type 2 (CB2) agonist, in preventing OA‐related joint damage. To test the assumption that HU308 could
Idan Carmon +10 more
wiley +1 more source