Results 61 to 70 of about 60,046 (266)

Differential cohesin loading marks paired and unpaired regions of platypus sex chromosomes at prophase I

Scientific Reports, 2017
Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and ...
Aaron E. Casey, Tasman J. Daish, Jose Luis Barbero, Frank Grützner   +3 more
doaj   +1 more source

Human male meiotic sex chromosome inactivation. [PDF]

PLoS ONE, 2012
In mammalian male gametogenesis the sex chromosomes are distinctive in both gene activity and epigenetic strategy. At first meiotic prophase the heteromorphic X and Y chromosomes are placed in a separate chromatin domain called the XY body.
Marieke de Vries, Sanne Vosters, Gerard Merkx, Kathleen D'Hauwers, Derick G Wansink, Liliana Ramos, Peter de Boer   +6 more
doaj   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Ultrastructural and immunocytochemical analysis of the XY body in rat and Guinea pig

European Journal of Histochemistry, 2009
The formation of the XY body involves the compaction of the extended chromatin to form a mesh of fibrogranular structures. During this process the ribonucleoprotein particles (RNP), which were associated with the chromatin filaments progressively ...
OM Echeverría, R Benavente, R Ortiz, GH Vázquez-Nin   +3 more
doaj   +1 more source

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

Single‐cell RNA‐sequencing of retrieved human oocytes and eggs in clinical practice and for human ovarian cell atlasing

Molecular Reproduction and Development, Volume 89, Issue 12, Page 597-607, December 2022., 2022
Abstract With the advancement of single‐cell separation techniques and high‐throughput sequencing platforms, single‐cell RNA‐sequencing (scRNA‐seq) has emerged as a vital technology for understanding tissue and organ systems at cellular resolution. Through transcriptional analysis, it is possible to characterize unique or rare cell types, interpret ...
Jordan H. Machlin, Ariella Shikanov
wiley   +1 more source

Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors. [PDF]

PLoS ONE, 2015
The eukaryotic genome is assembled into distinct types of chromatin. Gene-rich euchromatin has active chromatin marks, while heterochromatin is gene-poor and enriched for silencing marks.
Manasi S Apte, Victoria H Meller
doaj   +1 more source

Chromatin: a tunable spring at work inside chromosomes [PDF]

Physical Review E (1 november 2001), 2001
This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give for the first time the complete set of elastic constants (twist and bend persistence lengths, stretch modulus and twist-stretch coupling constant) of the so-called 30-nm chromatin fiber, in terms of DNA ...
arxiv   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

X‐linked ichthyosis: New insights into a multi‐system disorder

Skin Health and Disease, Volume 2, Issue 4, December 2022., 2022
X‐linked ichthyosis is a rare genetic skin condition. We discuss here how it is also associated with multiple medical conditions which may impact affected individuals' education, quality of life and mortality. Awareness and understanding of these comorbidities will be important for ensuring the best multidisplinary care for individuals with XLI ...
Georgina H. Wren, William Davies
wiley   +1 more source