Results 41 to 50 of about 15,433 (199)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

Exploration, EarlyView.
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR‐related mRNA at the 5' ss and 3' ss, generating two mature mRNA isoforms, which are ultimately translated into CSR‐related proteins. These CSR‐related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, thereby
Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen   +29 more
wiley   +1 more source

Comprehensive genetic and epigenetic characterization of Lynch‐like syndrome patients

International Journal of Cancer, EarlyView.
What's New? Lynch‐like syndrome is associated with development of colorectal cancer (CRC) with microsatellite instability and loss of expression of certain mismatch repair (MMR) genes, similar to Lynch syndrome, but unlike Lynch syndrome, the genetic cause of Lynch‐like syndrome (LLS) remains unknown.
Francesca Pirini, Luciano Calzari, Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Mila Ravegnani, Valentina Arcangeli, Alessandro Passardi, Elisabetta Petracci, Sara Bravaccini, Giorgia Marisi, Alessandra Viel, Daniela Barana, Monica Pedroni, Luca Roncucci, Daniele Calistri, Davide Gentilini   +18 more
wiley   +1 more source

Association Between Fetal Myocardial Alterations and Congenital Heart Disease Based on Post‐Mortem Myocardial MRI

iRADIOLOGY, EarlyView.
Applying myocardial parametric mapping based on post‐mortem MRI is feasible for non‐invasive tissue characterization. We speculated that the elevated T2 relaxation may be an essential myocardial tissue characterization of cyanotic congenital heart disease, potentially suggesting myocardial edema, which may provide evidence to guide appropriate ...
Weizeng Zheng, Xia Ying, Yuan Chen, Le Wang, Peiyue Jiang, Ying Jiang, Guohui Yan, Hong Wang, Yimin Zhou, Yun Liang, Yu Zou, Liqun Sun, Qiong Luo   +12 more
wiley   +1 more source

Intergenerational transmission of attachment: The role of intelligence

JCPP Advances, EarlyView.
Attachment and cognitive development are associated, but the direction of the association is unclear. Recently, Del Giudice and Haltigan have argued that attachment in childhood and attachment representations in adulthood are influenced by the cognitive capabilities of the individual, which might make the intergenerational transmission of attachment ...
Jana Runze, Marinus H. Van IJzendoorn, Annemieke M. Witte, Charlotte A. M. Cecil, Marian J. Bakermans‐Kranenburg   +4 more
wiley   +1 more source

CRISPR/Cas9‐mediated genome editing reveals seven testis‐enriched transmembrane glycoproteins dispensable for male fertility in mice

Andrology, EarlyView., 2023
Abstract Background Mammalian fertilization is mediated by multiple sperm acrosomal proteins, many of which are testis‐enriched transmembrane glycoproteins expressed during spermiogenesis (e.g., Izumo sperm‐egg fusion 1, Sperm acrosome associated 6, and Transmembrane protein 95).
Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin‐Yi Chang, Masahito Ikawa   +4 more
wiley   +1 more source

ATAC‐seq in Emerging Model Organisms: Challenges and Strategies

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Principle of ATAC‐seq (left), overview of arthropod species with published ATAC‐seq data (middle), summary of experimental design (right). ABSTRACT The Assay for Transposase‐Accessible Chromatin with sequencing (ATAC‐seq) is a versatile and widely utilized method for identifying potential regulatory regions, such as promoters and enhancers, within a ...
Duğçar Ebrar Erdoğan, Shadi Karimifard, Mozhgan Khodadadi, Liucong Ling, Luisa Linke, Ana Catalán, Vincent Doublet, Amanda Glaser‐Schmitt, Oliver Niehuis, Katja Nowick, Antonella Soro, Natascha Turetzek, Barbara Feldmeyer, Nico Posnien   +13 more
wiley   +1 more source

Expanding the Estimated Fetal Weight Definition of Growth Restriction by Adding Small Abdominal Circumference

Journal of Ultrasound in Medicine, EarlyView.
Objective The Society for Maternal‐Fetal Medicine's (SMFM) diagnostic criteria for fetal growth restriction (FGR) recently added abdominal circumference (AC) <10th percentile to estimated fetal weight (EFW) <10th percentile; however, its prediction of neonatal morbidity is unknown.
Ashley Shea, Ashley N. Battarbee, Katherine L. Grantz, Dian He, John Owen   +4 more
wiley   +1 more source

Lipid and lipoprotein particle profiles in patients with type 2 diabetes mellitus: A comparative study between highlanders and lowlanders

Lipids, EarlyView.
Abstract The lipid profiles of highlanders and lowlanders differ. However, studies of the lipid profiles of patients with type 2 diabetes mellitus (T2DM) living at high altitudes are limited. This study aimed to compare lipid profiles and lipoprotein particles in individuals with T2DM permanently residing in the Tibetan Plateau and those residing in ...
Chenghui Zhang, Rong Du, Suyuan Wang, Yan Ye, Xueping Sun, Yunhong Wu, Mingxia Li   +6 more
wiley   +1 more source

Polygenic Risk Score Combined with Transcranial Sonography Refines Parkinson's Disease Risk Prediction

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dopaminergic neuron depletion in the substantia nigra (SN) and the pathological aggregation of α‐synuclein are the neuropathological hallmarks of Parkinson's disease (PD). Objectives This study aimed to investigate the association between the polygenic risk score for PD (PD‐PRS) and transcranial sonography (TCS)‐measured SN ...
Mart Kals, Anu Reigo, Maris Teder‐Laving, Mariliis Vaht, Estonian Biobank research team, Lili Milani, Reedik Mägi, Mari Nelis, Georgi Hudjašov, Tiit Nikopensius, Andres Metspalu, Toomas Toomsoo   +11 more
wiley   +1 more source