Results 51 to 60 of about 15,433 (199)

Preserved Thermoregulation in Huntington's Disease: Insights from an Observational Case–Control Study

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Thermoregulation is critical for preventing hyperthermia during physical activity. In Huntington's disease (HD), research on possible thermoregulatory alterations has received little attention. Objectives We aimed to investigate and compare skin temperature differences before and after exercise between HD patients and healthy ...
Lucía Simón‐Vicente, Jéssica Rivadeneyra‐Posadas, María Soto‐Célix, Javier Raya‐González, Alejandro Rodríguez‐Fernández, Daniel Castillo‐Alvira, Fernando Vázquez, Esther Cubo   +7 more
wiley   +1 more source

Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods Forty‐nine subjects carrying mutant Huntingtin (mHTT), comprising 35 manifest (mHD) and 14 pre‐manifest (PreHD), and 35 healthy controls (HC) were recruited in this study.
Jin‐Hui Yin, Ling‐Xiao Cao, Ya‐Ou Liu, Yue Huang   +3 more
wiley   +1 more source

Genetics Influences Telomere Length in Parkinson's Disease: A Study in Monozygotic Discordant Twins

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) results from complex interactions among environmental, genetic, and aging factors. Telomeres, which ensure chromosome stability, naturally shorten with cell division, contributing to aging and cellular senescence.
Letizia Straniero, Valeria Rimoldi, Emanuele Cereda, Giulia Soldà, Daniela Calandrella, Stefano Duga, Samanta Mazzetti, Graziella Cappelletti, Ioannis U. Isaias, Gianni Pezzoli, Rosanna Asselta   +10 more
wiley   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

New Plant Protection, EarlyView.
Applying population genomics, this study revealed that Pst exhibits slower linkage disequilibrium decay compared to rust fungi with known sexual reproduction, identified extensive hard and soft sweeps linked to Pst adaptation, and demonstrated that crop domestication and breeding programs have significantly influenced pathogen population sizes ...
Yun Xing, Chongjing Xia, Liang Huang, Na Zhao, Hongfu Li, Xingzong Zhang, Age Qiu, Wanqiang Tang, Meinan Wang, Xianming Chen, Bo Liu, Hao Zhang, Li Gao, Wanquan Chen, Taiguo Liu   +14 more
wiley   +1 more source

Opioid Analgesia Following Pediatric Adenotonsillectomy: A Randomized Clinical Trial

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To compare the safety and efficacy of nonopioid versus opioid pain management following adenotonsillectomy (AT) among pediatric patients. Study Design An open‐label randomized controlled trial. Setting Tertiary care children's hospital. Methods Patients aged 3 to 17 years undergoing AT were eligible.
Rachel L. Whelan, Jennifer L. McCoy, Leonid Mirson, Raymond C. Maguire, Noel Jabbour, Jeffrey P. Simons, Joseph E. Dohar, Dennis J. Kitsko, Amanda L. Stapleton, Allison B.J. Tobey, Cuneyt M. Alper, Amber D. Shaffer, Zachary R. Bennett, David H. Chi   +13 more
wiley   +1 more source

Prognosis of Dysphagia in Pediatric Patients With Vocal Fold Immobility

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective This study aims to determine the incidence and prognosis of dysphagia in pediatric patients with true vocal fold (TVF) immobility or hypomobility. Study Design A single‐center retrospective chart review. Setting A single‐institution tertiary‐care center.
Rachel Georgopoulos, Khashayar Arianpour, Samantha Anne   +2 more
wiley   +1 more source

Genetic Diagnosis and Clinical Features of Fetuses With Congenital Diaphragmatic Hernia

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Congenital diaphragmatic hernia (CDH) is a rare abnormality with highly heterogeneous genetic causes. This study investigated chromosomal and monogenic abnormalities in fetal CDH patients and evaluated the efficacy of chromosomal microarray analysis (CMA) and whole‐exome sequencing (WES) for genetic diagnosis.
Yan Lü, Yi Yu, Jiazhen Chang, Mengmeng Li, Xueting Yang, Xiya Zhou, Na Hao, Hua Meng, Zhenghong Li, Lishuang Ma, Hui You, Shan Jian, Ying Wang, Shengjie Li, Yiqing Yu, Kaili Yin, Mingming Wang, Yulin Jiang, Qingwei Qi   +18 more
wiley   +1 more source

Screening Positive for Rare Autosomal Aneuploidies Increases Frequency of Adverse Pregnancy Outcomes and Alters Clinical Management

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Outcomes in pregnancies with rare autosomal aneuploidies (RAAs) are poorly characterized, with most studies having small sample sizes. Here, we describe outcomes and management in a large cohort of pregnancies that screened positive for an RAA (RAA+).
Devika Chawla, D. Claire Miller, Summer Pierson, Lyuba Popadic, Francesca Devine, Dallas Reed, Katherine Johansen Taber   +6 more
wiley   +1 more source

Clinical Outcome and Risk Factors for Progression of Prenatally Diagnosed Fetal Ventriculomegaly: A Retrospective Multicenter Study

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To investigate the clinical outcome of fetuses with ventriculomegaly (VM), and to identify risk factors for progression of fetal VM in order to improve prenatal counseling. This was a multicenter, retrospective cohort study, comprising 229 cases with VM.
Anouk Moens, Zoe Albersnagel, Marieke B. Veenhof, Phebe N. Adama van Scheltema, Esther Sikkel, Mariëtte J. V. Hoffer, Brigitte H. W. Faas, Dineke Westra, Ilse Feenstra, Emilia K. Bijlsma, Gijs W. E. Santen, Corrie E. Erasmus, Cacha M. P. C. D. Peeters‐Scholte   +12 more
wiley   +1 more source