Results 91 to 100 of about 1,619,726 (301)

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Cross-species chromosome painting tracks the independent origin of multiple sex chromosomes in two cofamiliar Erythrinidae fishes

BMC Evolutionary Biology, 2011
Background The Erythrinidae fish family is characterized by a large variation with respect to diploid chromosome numbers and sex-determining systems among its species, including two multiple X1X2Y sex systems in Hoplias malabaricus and Erythrinus ...
Trifonov Vladimir, Liehr Thomas, Kosyakova Nadezda, Marchal Juan A, Sánchez Antonio, Cioffi Marcelo B, Bertollo Luiz AC   +6 more
doaj   +1 more source

Sex Chromosomes

, 1967
Sex Chromosomes focuses on the study of sex chromosomes, including human chromosomal abnormalities, behavior and characteristics of chromosomes, and cell division.
Mittwoch, Ursula
core  

Neo-sex chromosomes and their evolutionary significance [PDF]

, 2017
Neo-sex chromosomes arise due to rearrangements between ancestral gonosomes and autosomes. Neo-sex chromosomes are valuable systems for the study of sex chromosome evolution.
Košátko, Prokop
core  

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Evolutionary dynamics of autosomal-heterosomal rearrangements in a multiple-X chromosome system of tiger beetles (Cicindelidae)

BMC Evolutionary Biology, 2007
Background Genetic systems involving multiple X chromosomes have arisen repeatedly in sexually reproducing animals. Tiger beetles (Cicindelidae) exhibit a phylogenetically ancient multiple-X system typically consisting of 2–4 X chromosomes and a single Y.
Vogler Alfried P, Proença Sónia JR, Galián José   +2 more
doaj   +1 more source

Identification of Putative Sex Chromosomes in the Blue Tilapia, Oreochromis Aureus, through Synaptonemal Complex and FISH Analysis

, 2001
Sex determination in the blue tilapia, Oreochromis aureus, is primarily a ZW female-ZZ male system. Here, by analysis of the pachytene meiotic chromosomes of O.
Carrasco, L., Carrasco, LAP, Bromage, Niall R, Harvey, SC, McAndrew, B., Masabanda, Julio, Masabanda, JS, Harvey, Simon C, Campos-Ramos, R, Harvey, S., McAndrew, BJ, Penman, DJ, Bromage, N., Penman, David, Griffin, DK, Masabanda, J., Campos-Ramos, Rafael, Carrasco, Luis A P, Bromage, NR, Griffin, Darren K, Griffin, D., McAndrew, Brendan, Penman, D., Campos-Ramos, R., Masabanda, Julio S., Carrasco, Luis Roman, Harvey, Simon C., Bromage, Niall R., Penman, David J., McAndrew, B.J., Griffin, Darren K.   +30 more
core   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Dosage compensation in birds [PDF]

, 2001
The Z and W sex chromosomes of birds have evolved independently from the mammalian X and Y chromosomes [1]. Unlike mammals, female birds are heterogametic (ZW), while males are homogametic (ZZ).
Derek McBride, McQueen, H A; id_orcid, Gino Miele, McBride, D, Miele, G, Clinton, M, Bird, A P; id_orcid, Heather A McQueen, Michael Clinton, Adrian P Bird   +9 more
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source