Results 71 to 80 of about 1,619,726 (301)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Allopolyploidization from two dioecious ancestors leads to recurrent evolution of sex chromosomes

Nature Communications
Polyploidization presents an unusual challenge for species with sex chromosomes, as it can lead to complex combinations of sex chromosomes that disrupt reproductive development.
Li He, Yuàn Wang, Yi Wang, Ren-Gang Zhang, Yuán Wang, Elvira Hörandl, Tao Ma, Yan-Fei Mao, Judith E. Mank, Ray Ming   +9 more
doaj   +1 more source

Kinetic activity of the sex chromosomes of Mormidea paupercula (Heteroptera: Pentatomidae)

European Journal of Entomology, 2010
In Mormidea paupercula (n = 6 + XY in males), the presence of a CMA3-bright band in the telomeric regions on both sex chromosomes allowed the analysis of the kinetic activity of the sex univalents and XY pseudobivalent at the first and second meiotic ...
Pablo Javier REBAGLIATI, Liliana María MOLA   +1 more
doaj   +1 more source

The Methylome of Vertebrate Sex Chromosomes [PDF]

Genes, 2018
DNA methylation is a key epigenetic modification in vertebrate genomes known to be involved in the regulation of gene expression, X chromosome inactivation, genomic imprinting, chromatin structure, and control of transposable elements. DNA methylation is common to all eukaryote genomes, but we still lack a complete understanding of the variation in DNA
Waters, SA, Capraro, A, McIntyre, KL, Graves, JAM, Waters, PD   +4 more
openaire   +3 more sources

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Heteromorphic ZZ/ZW sex chromosomes sharing gene content with mammalian XX/XY are conserved in Madagascan chameleons of the genus Furcifer

Scientific Reports
Chameleons are well-known lizards with unique morphology and physiology, but their sex determination has remained poorly studied. Madagascan chameleons of the genus Furcifer have cytogenetically distinct Z and W sex chromosomes and occasionally Z1Z1Z2Z2 ...
Michail Rovatsos, Sofia Mazzoleni, Barbora Augstenová, Marie Altmanová, Petr Velenský, Frank Glaw, Antonio Sanchez, Lukáš Kratochvíl   +7 more
doaj   +1 more source

Sex chromosomes of Nematocera [PDF]

, 2022
The paraphyletic group Nematocera is highly diversified in both body morphology and life strategies. Based on sex chromosome morphology, it can be divided into four groups defined as early as the mid- 20th century.
Ryšan, Tadeáš
core  

Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans

Nature Communications, 2021
During meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex ...
Yisrael Rappaport, Hanna Achache, Roni Falk, Omer Murik, Oren Ram, Yonatan B. Tzur   +5 more
doaj   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Evolutionary pattern of karyotypes and meiosis in pholcid spiders (Araneae: Pholcidae): implications for reconstructing chromosome evolution of araneomorph spiders

BMC Ecology and Evolution, 2021
Background Despite progress in genomic analysis of spiders, their chromosome evolution is not satisfactorily understood. Most information on spider chromosomes concerns the most diversified clade, entelegyne araneomorphs.
Ivalú M. Ávila Herrera, Jiří Král, Markéta Pastuchová, Martin Forman, Jana Musilová, Tereza Kořínková, František Šťáhlavský, Magda Zrzavá, Petr Nguyen, Pavel Just, Charles R. Haddad, Matyáš Hiřman, Martina Koubová, David Sadílek, Bernhard A. Huber   +14 more
doaj   +1 more source