Results 51 to 60 of about 88,308 (262)

Molecular sexing and population genetic inference using a sex-linked microsatellite marker in the nine-spined stickleback (Pungitius pungitius)

BMC Research Notes, 2011
Background Sex-specific DNA markers can serve as tools for molecular sex identification, as well as for population genetic inferences. We investigated the potential utility of a microsatellite marker located on sex chromosomes for molecular sexing of ...
Merilä Juha, Herczeg Gábor, Shikano Takahito   +2 more
doaj   +1 more source

Evolutionary pattern of karyotypes and meiosis in pholcid spiders (Araneae: Pholcidae): implications for reconstructing chromosome evolution of araneomorph spiders

BMC Ecology and Evolution, 2021
Background Despite progress in genomic analysis of spiders, their chromosome evolution is not satisfactorily understood. Most information on spider chromosomes concerns the most diversified clade, entelegyne araneomorphs.
Ivalú M. Ávila Herrera, Jiří Král, Markéta Pastuchová, Martin Forman, Jana Musilová, Tereza Kořínková, František Šťáhlavský, Magda Zrzavá, Petr Nguyen, Pavel Just, Charles R. Haddad, Matyáš Hiřman, Martina Koubová, David Sadílek, Bernhard A. Huber   +14 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A state-of-art review of Loricariidae (Ostariophysi: Siluriformes) cytogenetics [PDF]

Neotropical Ichthyology
Loricariidae is a Neotropical fish family divided into six subfamilies and ranking in third among the most biodiverse fish groups. This study conducts an updated review of the cytogenetic investigations within the family, discussing the trends in ...
Francisco de Menezes Cavalcante Sassi, Marcelo de Bello Cioffi, Orlando Moreira-Filho   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Cross-species chromosome painting tracks the independent origin of multiple sex chromosomes in two cofamiliar Erythrinidae fishes

BMC Evolutionary Biology, 2011
Background The Erythrinidae fish family is characterized by a large variation with respect to diploid chromosome numbers and sex-determining systems among its species, including two multiple X1X2Y sex systems in Hoplias malabaricus and Erythrinus ...
Trifonov Vladimir, Liehr Thomas, Kosyakova Nadezda, Marchal Juan A, Sánchez Antonio, Cioffi Marcelo B, Bertollo Luiz AC   +6 more
doaj   +1 more source

The wild grape genome sequence provides insights into the transition from dioecy to hermaphroditism during grape domestication

Genome Biology, 2020
Background A key step in domestication of the grapevine was the transition from separate sexes (dioecy) in wild Vitis vinifera ssp. sylvestris (V. sylvestris) to hermaphroditism in cultivated Vitis vinifera ssp. sativa (V. vinifera).
Hélène Badouin, Amandine Velt, François Gindraud, Timothée Flutre, Vincent Dumas, Sonia Vautrin, William Marande, Jonathan Corbi, Erika Sallet, Jérémy Ganofsky, Sylvain Santoni, Dominique Guyot, Eugenia Ricciardelli, Kristen Jepsen, Jos Käfer, Hélène Berges, Eric Duchêne, Franck Picard, Philippe Hugueney, Raquel Tavares, Roberto Bacilieri, Camille Rustenholz, Gabriel A. B. Marais   +22 more
doaj   +1 more source

Highly differentiated ZW sex microchromosomes in the Australian Varanus species evolved through rapid amplification of repetitive sequences. [PDF]

PLoS ONE, 2014
Transitions between sex determination systems have occurred in many lineages of squamates and it follows that novel sex chromosomes will also have arisen multiple times.
Kazumi Matsubara, Stephen D Sarre, Arthur Georges, Yoichi Matsuda, Jennifer A Marshall Graves, Tariq Ezaz   +5 more
doaj   +1 more source

Sex Steroids and Sex Chromosomes at Odds? [PDF]

Endocrinology, 2005
Alfred Jost’s proposal in the 1940s (1) that testes are crucial for the development of the male phenotype, and that without them the body develops in a female direction, has been driving research in the field of sexual differentiation for more than half a century.
openaire   +2 more sources