Results 61 to 70 of about 1,541,356 (256)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Karyotyping human chromosomes by optical and X-ray ptychography methods [PDF]

, 2014
Sorting and identifying chromosomes, a process known as karyotyping, is widely used to detect changes in chromosome shapes and gene positions. In a karyotype the chromosomes are identified by their size and therefore this process can be performed by ...
Xiong, G, Harder, Ross, Robinson, Ian K., Robinson, IK, Shemilt, Laura, Yusuf, M, Shemilt, LA, Verbanis, E, Estandarte, AK, Zhang, F, Zhang, Fucai, Schwenke, J, Xiong, Gang, Yusuf, Mohammed, Parmar, Neha, Schwenke, Joerg, Parmar, N, Verbanis, Ephanielle, Estandarte, Ana K.   +18 more
core   +1 more source

Allopolyploidization from two dioecious ancestors leads to recurrent evolution of sex chromosomes

Nature Communications
Polyploidization presents an unusual challenge for species with sex chromosomes, as it can lead to complex combinations of sex chromosomes that disrupt reproductive development.
Li He, Yuàn Wang, Yi Wang, Ren-Gang Zhang, Yuán Wang, Elvira Hörandl, Tao Ma, Yan-Fei Mao, Judith E. Mank, Ray Ming   +9 more
doaj   +1 more source

Chromosome complement and meiosis in three species of the Neotropical bug genus Antiteuchus (Heteroptera, Pentatomidae, Discocephalinae)

Genetics and Molecular Biology, 2006
Orcein staining of spermatocytes was used to study the meiotic behavior of holocentric chromosomes in three member of the genus Antiteuchus (commonly known as stink bugs). We describe and illustrate the karyotype of Antiteuchus mixtus, A. sepulcralis and
Cecilia Lanzone, Maria José de Souza
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Analysis of repetitive DNA sequences in the sex chromosomes of Oreochromis niloticus

, 2003
In the Nile tilapia, Oreochromis niloticus, sex determination is primarily genetic, with XX females and XY males. While the X and Y chromosomes (the largest pair) cannot be distinguished in mitotic chromosome spreads, analysis of comparative ...
Ezaz, Tariq; id_orcid, Boonphakdee, C., Harvey, Simon, Griffin, D. K., Campos-Ramos, Rafael, Harvey, S., Ezaz, M.T., Harvey, Simon C., Bromage, Niall R., Penman, P., Griffin, D., Ezaz, M., Bromage, N. R., Penman, D., Griffin, Darren K., Campos-Ramos, R., Bromage, N., Boomphakdee, Chuta   +17 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Sex chromosomes of Nematocera [PDF]

, 2022
The paraphyletic group Nematocera is highly diversified in both body morphology and life strategies. Based on sex chromosome morphology, it can be divided into four groups defined as early as the mid- 20th century.
Ryšan, Tadeáš
core  

The sex chromosomes of the aging epigenome [PDF]

, 2020
Sex chromosomes are specialized chromosomes that determine the sex of individuals. They differ from an ordinary autosome in form, size, and behavior.
Tan, Qihua; id_orcid
core   +1 more source

Evolutionary pattern of karyotypes and meiosis in pholcid spiders (Araneae: Pholcidae): implications for reconstructing chromosome evolution of araneomorph spiders

BMC Ecology and Evolution, 2021
Background Despite progress in genomic analysis of spiders, their chromosome evolution is not satisfactorily understood. Most information on spider chromosomes concerns the most diversified clade, entelegyne araneomorphs.
Ivalú M. Ávila Herrera, Jiří Král, Markéta Pastuchová, Martin Forman, Jana Musilová, Tereza Kořínková, František Šťáhlavský, Magda Zrzavá, Petr Nguyen, Pavel Just, Charles R. Haddad, Matyáš Hiřman, Martina Koubová, David Sadílek, Bernhard A. Huber   +14 more
doaj   +1 more source