Results 191 to 200 of about 92,922 (310)

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe   +6 more
wiley   +1 more source

Preoperative Detection of Dual TERT Promoter Mutations in Thyroid Cancer: A Case Series

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Telomerase reverse transcriptase promoter (TERTp) mutations are associated with aggressive thyroid cancer and are most frequently found in anaplastic and poorly differentiated thyroid cancer. Pre‐operative thyroid nodule molecular testing can detect TERTp, denoting a high risk of malignancy and possible aggressive clinical features such as ...
Amir Harari   +7 more
wiley   +1 more source

The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY

open access: green, 2012
Sasidhar Venkata Manda   +4 more
openalex   +1 more source

Oogenesis and germinal bed morphology of the brown anole (A. sagrei)

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The brown anole is a model species of the genus Anolis, a squamate (encompassing lizards and snakes) group widely studied in evolutionary, behavioral, and developmental biology. Full genome annotation, the establishment of gene editing techniques, and comprehensive description of reproductive tract morphology and embryogenesis in ...
Bonnie K. Kircher   +12 more
wiley   +1 more source

Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain. [PDF]

open access: yesProc Natl Acad Sci U S A
Compton A   +8 more
europepmc   +1 more source

Reviewing Research on Transgender and Nonbinary People in Social Psychology: Insights and Future Research Directions

open access: yesEuropean Journal of Social Psychology, EarlyView.
ABSTRACT Transgender and nonbinary (TGNB) identities and issues faced by TGNB people are receiving growing attention in social psychology. At the same time, this is a relatively new area, and most research on LGBTQ+ issues primarily focuses on sexual minorities, whereas most research on gender focuses on women and men.
Thekla Morgenroth, Kira Kay Means
wiley   +1 more source

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