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Sex determination

Human Molecular Genetics, 1994
The cloning of the 'testis determining gene', SRY, promised a revolution in the understanding of sex determination in humans. The failure to isolate further genes involved in sex determination has been a disappointment. The biology of SRY, however, has kept the field exciting. The discoveries of sex reversing SRY mutations with variable penetrance, but
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Sex chromosomes and sex determination in reptiles

Current Opinion in Genetics & Development, 2005
Reptiles occupy a crucial position with respect to vertebrate phylogeny, having roamed the earth for more than 300 million years and given rise to both birds and mammals. To date, this group has been largely ignored by contemporary genomics technologies, although the green anole lizard was recently recommended for whole genome sequencing.
William S, Modi, David, Crews
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Sex Chromosomes and Sex Determination in Lepidoptera

Sexual Development, 2007
The speciose insect order Lepidoptera (moths and butterflies) and their closest relatives, Trichoptera (caddis flies), share a female-heterogametic sex chromosome system. Originally a Z/ZZ (female/male) system, it evolved by chromosome rearrangement to a WZ/ZZ (female/male) system in the most species-rich branch of Lepidoptera, a monophyletic group ...
W, Traut, K, Sahara, F, Marec
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Determination and stability of sex

BioEssays, 2006
AbstractHow is the embryonic bipotential gonad regulated to produce either an ovary or a testis? In males, transient early activation of the Y chromosome Sry gene makes both germ cells and soma male. However, in females, available evidence suggests that the process of ovary sex determination may take place independently in the germline and somatic ...
Ottolenghi C   +6 more
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Sex Determination: Turning on sex

Current Biology, 1994
The orphan nuclear receptor, steroidogenic factor 1, is central to the differentiation of male and female mammalian gonads. It controls the fate of the initially bipotential gonad as well as later male-specific functions.
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Sex-Determining Genes

Trends in Endocrinology & Metabolism, 1997
Recently, a number of genes have been identified that are associated with a failure of human sex determination, including WT1, DAX-1, SOX9, ATRX, and the Y-linked testis determination gene, SRY. Most cases of human sex reversal, XY females and XX males, do not, however, appear to be caused by mutations in these genes.
K, McElreavey, M, Fellous
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Genomics of sex determination

Current Opinion in Plant Biology, 2014
Sex determination is a major switch in the evolutionary history of angiosperm, resulting 11% monoecious and dioecious species. The genomic sequences of papaya sex chromosomes unveiled the molecular basis of recombination suppression in the sex determination region, and candidate genes for sex determination.
Zhang, Jisen   +3 more
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Sex Determination and Sex Chromosomes in Amphibia

Sexual Development, 2017
Sex chromosomes in most amphibians are homomorphic (undifferentiated) in both sexes and are characterized by frequent turnover. This is in sharp contrast to sex chromosomes in 2 major vertebrate groups, the mammals and birds, where they are heteromorphic in one sex and are highly conserved.
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Sex determination in plants

Current Opinion in Plant Biology, 1998
Sex determination is an important developmental event in the life cycle of all sexually reproducing plants. Recent studies of sex determination in many plant species, from ferns to maize, have been fruitful in identifying the diversity of genetic and epigenetic factors that are involved in determining the sex of the flower or individual.
C, Juarez, J A, Banks
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Sex determination in mammals

Trends in Genetics, 1988
Abstract Studies on people and mice with sex chromosome abnormalities have established that the gene switching embryonic development into the male rather than the female pathway is located on the short arm of the Y chromosome in both species. How the gene exerts its effects is still a mystery.
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