Results 61 to 70 of about 98,853 (294)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Sex determination mode does not affect body or genital development of the central bearded dragon (Pogona vitticeps)

open access: yesEvoDevo, 2017
Background The development of male- or female-specific phenotypes in squamates is typically controlled by either temperature-dependent sex determination (TSD) or chromosome-based genetic sex determination (GSD).
Sarah L. Whiteley   +7 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements

open access: yesBMC Biology, 2018
Background Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-functionalization, also requires the ...
Manfred Schartl   +11 more
doaj   +1 more source

Sex determination, adaptive divergence, and the role of inversions in ecotypes of the intertidal snail Littorina saxatilis [PDF]

open access: yes, 2023
Sex determination and sex chromosomes exhibit great diversity within and between species, in their mechanisms and drivers, and over space and time. Why and how this variation has evolved remains poorly understood and empirical evidence remains scarce ...
Hearn, Katherine Elizabeth
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis

open access: yesBMC Genomics, 2009
Background Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms.
Arbeitman Michelle N   +3 more
doaj   +1 more source

Expectation-Maximization Algorithm for Determining Natural Selection of Y-Linked Genes Through Two-Sex Branching Processes [PDF]

open access: yesJournal of Computational Biology, 2012
A two-dimensional bisexual branching process has recently been presented for the analysis of the generation-to-generation evolution of the number of carriers of a Y-linked gene. In this model, preference of females for males with a specific genetic characteristic is assumed to be determined by an allele of the gene.
Miguel González 0002   +2 more
openaire   +2 more sources

Does predation control adult sex ratios and longevities in marine pelagic copepods? [PDF]

open access: yes, 2010
We assess the causes of adult sex ratio skew in marine pelagic copepods by examining changes in these ratios between the juveniles and adults, sexual differences in juvenile stage durations, and mortality rates of adults in the field and laboratory (when
Bonnet, D.   +11 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

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