Results 91 to 100 of about 1,927,890 (314)

The relationship between epicardial adipose tissue and coronary artery stenosis by sex and menopausal status in patients with suspected angina

Biology of Sex Differences, 2018
Background Evidence suggests that epicardial adipose tissue (EAT) is closely related to coronary artery stenosis (CAS). However, sexual dimorphism may be present in adipose tissue, and its influence on CAS between men and women is controversial.
Mi-Na Kim, Seong-Mi Park, Dong-Hyuk Cho, Hack-Lyoung Kim, Mi-Seung Shin, Myung-A Kim, Kyung-Soon Hong, Wan-Joo Shim   +7 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Sex-specific-differences in cardiovascular risk in type-1-diabetes : a cross sectional study [PDF]

, 2013
Background: Little is known about the impact of sex-specific differences in the management of type 1 diabetes (T1DM). Thus, we evaluated the influence of gender on risk factors, complications, clinical care and adherence in patients with T1DM.
Kautzky, Alexander, Saukel, Johannes (Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna), Stich, Kathrin (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Alexander Kautzky, Kautzky, Alexander (Gender Medicine Unit, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna), Hintersteiner, Juliane (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Kautzky-Willer, Alexandra (Gender Medicine Unit, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna), Johannes Saukel, Kautzky-Willer, Alexandra, Stich, Kathrin, Lemmens-Gruber, Rosa, Lemmens-Gruber, Rosa (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Saukel, Johannes, Majid Kamyar, Johnson, Julienne, Juliane Hintersteiner, Hinstersteiner, Juliane, Kamyar, Majid (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Alexandra Kautzky-Willer, Kathrin Stich, Johnson, Julienne (Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University), Kamyar, Majid Reza, Julienne Johnson, Rosa Lemmens-Gruber   +23 more
core   +1 more source

The influence of sex on neuroimmune communication, pain, and physiology

Biology of Sex Differences
With the National Institutes of Health’s mandate to consider sex as a biological variable (SABV), there has been a significant increase of studies utilizing both sexes.
Shevon N. Alexander, Audrey R. Green, Emily K. Debner, Lindsey E. Ramos Freitas, Hanna M. K. Abdelhadi, Thomas A. Szabo-Pardi, Michael D. Burton   +6 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity

Biology of Sex Differences
Background Male sex has been identified as a risk factor for worse COVID-19 outcomes. This sex difference has been mostly attributed to the complex role of sex hormones. Cell surface entry of SARS-CoV-2 is mediated by the transmembrane protease serine 2 (
Eric C. Mohan, Jude P. J. Savarraj, Gabriela D. Colpo, Diego Morales, Carson E. Finger, Alexis McAlister, Hilda Ahnstedt, HuiMahn Choi, Louise D. McCullough, Bharti Manwani   +9 more
doaj   +1 more source

Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse

Biology of Sex Differences, 2019
The response to overfeeding is sex dependent, and metabolic syndrome is more likely associated to obesity in men or postmenopausal women than in young fertile women.
Marcela González-Granillo, Luisa A. Helguero, Eliana Alves, Amena Archer, Christina Savva, Matteo Pedrelli, Osman Ahmed, Xidan Li, Maria Rosário Domingues, Paolo Parini, Jan-Åke Gustafsson, Marion Korach-André   +11 more
doaj   +1 more source

Sex differences in muscle activity and motor variability in response to a non-fatiguing repetitive screwing task

Biology of Sex Differences, 2020
Background Musculoskeletal disorders are more prevalent among women than among men, which may be explained by aspects of motor control, including neuromuscular requirements and motor variability.
Tessy Luger, Robert Seibt, Monika A. Rieger, Benjamin Steinhilber   +3 more
doaj   +1 more source

Sex differences in schizophrenia

International Review of Psychiatry, 2010
Evidence suggests sex differences in schizophrenia reflect differences in both neurodevelopmental processes and social effects on disease risk and course. Male:female incidence approximates 1.4:1 but at older onset women predominate. Prevalence differences appear smaller.
Abel, Kathryn M., Drake, Richard; id_orcid 0000-0003-0220-4835, Goldstein, Jill M.   +2 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source