Results 71 to 80 of about 3,542,232 (293)

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2007
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Mittelstrass, Kirstin, Ried, Janina S., Yu, Zhonghao, Krumsiek, Jan, Gieger, Christian, Prehn, Cornelia, Roemisch-Margl, Werner, Polonikov, Alexey, Peters, Annette, Theis, Fabian J., Meitinger, Thomas, Kronenberg, Florian, Weidinger, Stephan, Wichmann, Heinz-Erich, Suhre, Karsten, Wang-Sattler, Rui, Adamski, Jerzy, Illig, Thomas   +17 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer’s disease

Biology of Sex Differences
Background Menopausal loss of neuroprotective estrogen is thought to contribute to the sex differences in Alzheimer’s disease (AD). Activation of estrogen receptor beta (ERβ) can be clinically relevant since it avoids the adverse systemic effects of ERα ...
Aphrodite Demetriou, Birgitta Lindqvist, Heba G. Ali, Mohamed M. Shamekh, Mukesh Varshney, Jose Inzunza, Silvia Maioli, Per Nilsson, Ivan Nalvarte   +8 more
doaj   +1 more source

Sexually dimorphic effect of aging on skeletal muscle protein synthesis

Biology of Sex Differences, 2012
Background Although there appear to be no differences in muscle protein turnover in young and middle aged men and women, we have reported significant differences in the rate of muscle protein synthesis between older adult men and women.
Smith Gordon I, Reeds Dominic N, Hall Angela M, Chambers Kari T, Finck Brian N, Mittendorfer Bettina   +5 more
doaj   +1 more source

Sexually size dimorphic brains and song complexity in passerine birds [PDF]

, 2004
Neural correlates of bird song involve the volume of particular song nuclei in the brain that govern song development, production, and perception. Intra- and interspecific variation in the volume of these song nuclei are associated with overall brain ...
Eens, Marcel, Erritzoe, Johannes, Garamszegi, László Zsolt, Moller, Anders Pape   +3 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease

Biology of Sex Differences
Background Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. Methods In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale, human ...
Stuart B. Fass, Bernard Mulvey, Rebecca Chase, Wei Yang, Din Selmanovic, Sneha M. Chaturvedi, Eric Tycksen, Lauren A. Weiss, Joseph D. Dougherty   +8 more
doaj   +1 more source

Sex steroid hormone modulation of neural stem cells: a critical review

Biology of Sex Differences, 2019
While numerous in vivo experiments have sought to explore the effects of sex chromosome composition and sex steroid hormones on cellular proliferation and differentiation within the mammalian brain, far fewer studies as reviewed here, have explored these
Matthew S. Bramble, Neerja Vashist, Eric Vilain   +2 more
doaj   +1 more source

Victim or whore: The similarities and differences between victim’s experiences of domestic violence and sex trafficking [PDF]

, 2014
This research review addresses the similarities and differences between domestic violence and sex trafficking victimization. While there is evidence that domestic violence and sex trafficking often cooccur, there is a large disparity in the ...
Dahlstedt, Jaime, Gallagher, James, Hickle, Kristine, Roe-Sepowitz, Dominique   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source