Results 71 to 80 of about 1,927,890 (314)

Age- and sex-associated alterations in hypothalamic mitochondrial bioenergetics and inflammatory-associated signaling in the 3xTg mouse model of Alzheimer’s disease

Biology of Sex Differences
Mitochondrial dysfunction and associated inflammatory signaling are pivotal in both aging and in Alzheimer’s disease (AD). Studies have also shown that hypothalamic function is affected in AD.
Aida Adlimoghaddam, Kyle M. Fontaine, Benedict C. Albensi   +2 more
doaj   +1 more source

The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis

Biology of Sex Differences, 2020
Background Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence, and outcome of cancer are different between the sexes.
Jianfang Rong, Sihai Chen, Conghua Song, Huan Wang, Qiaoyun Zhao, Rulin Zhao, Yajing He, Lili Yan, Yanping Song, Fangfei Wang, Yong Xie   +10 more
doaj   +1 more source

Sex Differences in Lifespan [PDF]

Cell Metabolism, 2016
Sex differences in longevity can provide insights into novel mechanisms of aging, yet they have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild animals. Evolutionary hypotheses accounting for longevity patterns in natural populations include differential vulnerability to environmental hazards, differential ...
Steven N, Austad, Kathleen E, Fischer
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Influences of sex and gender on the associations between risk and protective factors, brain, and behavior

Biology of Sex Differences
Risk and protective factors for psychiatric illnesses are linked to distinct structural and functional changes in the brain. Further, the prevalence of these factors varies across sexes and genders, yet the distinct and joint effects of sex and gender in
Katharina Brosch, Elvisha Dhamala
doaj   +1 more source

Lean mass mediates the relation between temporal summation of pain and sex in young healthy adults

Biology of Sex Differences, 2018
Background Previous studies have shown that women experience greater temporal summation (TS) of pain than men using a repetitive thermal stimulus.
Abdulaziz Awali, Ali M. Alsouhibani, Marie Hoeger Bement   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Sex Differences in Inflammation During Atherosclerosis

, 2014
Atherosclerosis is the leading cause of death in the United States and worldwide, yet more men die from atherosclerosis than women, and at a younger age.
DeLisa Fairweather
core   +1 more source

Coronary artery calcification and aortic valve calcification in patients with kidney failure : a sex-disaggregated study

, 2023
Background: Chronic kidney disease (CKD) is linked to an increased cardiovascular disease (CVD) burden. Albeit underappreciated, sex differences are evident in CKD with females being more prone to CKD development, but males progressing more rapidly to ...
Ward, Liam J.,, Laucyte-Cibulskiene, Agne, Hernandez, Leah,, Ward, L, Hernandez, Leah, Ripsweden, Jonaz, Laucyte-Cibulskiene, Agne,, Ripsweden, Jonaz,, Ripsweden, J,, Kublickiene, Karolina, Laucyte-Cibulskiene, A, Stenvinkel, Peter,, Kublickiene, K,, Stenvinkel, Peter, Stenvinkel, P,, Lund University., Ward, Liam J., Hernandez, L, GOING-FWD Collaborators, Kublickiene, Karolina,   +19 more
core   +1 more source

ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer’s disease

Biology of Sex Differences
Background Menopausal loss of neuroprotective estrogen is thought to contribute to the sex differences in Alzheimer’s disease (AD). Activation of estrogen receptor beta (ERβ) can be clinically relevant since it avoids the adverse systemic effects of ERα ...
Aphrodite Demetriou, Birgitta Lindqvist, Heba G. Ali, Mohamed M. Shamekh, Mukesh Varshney, Jose Inzunza, Silvia Maioli, Per Nilsson, Ivan Nalvarte   +8 more
doaj   +1 more source