Results 61 to 70 of about 18,963,221 (356)

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Sex differences in adenosine deaminase activity associate with disparities in SARS-CoV-2 innate immunity

iScience
Summary: Females demonstrate elevated type-I interferon production and a stronger antiviral immune response; however, the mechanisms underlying sex-based differences in antiviral immunity are incompletely understood.
Priyanka Saminathan, Ian T. Mathews, Ahmad Alimadadi, Kai Fung, Kiyokazu Kakugawa, Leo A.B. Joosten, Mihai G. Netea, Mohit Jain, Susan Cheng, Catherine C. Hedrick, Sonia Sharma   +10 more
doaj   +1 more source

Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses

Biology of Sex Differences, 2020
Estradiol and testosterone are powerful steroid hormones that impact brain function in numerous ways. During development, these hormones can act to program the adult brain in a male or female direction.
Damian G. Zuloaga, Ashley L. Heck, Rose M. De Guzman, Robert J. Handa   +3 more
doaj   +1 more source

Sex differences in vulnerability to addiction

Neuropharmacology, 2021
This article reviews the evidence for sex differences in vulnerability to addiction with an emphasis on the neural mechanisms underlying these differences.
Jacqueline A. Quigley, Molly K. Logsdon, Christopher A. Turner, I. Gonzalez, Noah Leonardo, J. Becker   +5 more
semanticscholar   +1 more source

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

Gender Identity and Preferences in Children with Variations in Sex Development

JCRPE
Objective: To assess gender-typed preferences and gender identity in children with and without variations in sex developments (VSDs). Methods: In this cross-sectional study, 78 children with VSDs (ages 3-12; mean age=7 years; 55% White, non-Hispanic ...
Canice E. Crerand, Natalie M. Gallagher, Margaret P. Adam, Maria G. Vogiatzi, Elizabeth McCauley, Jennifer Hansen-Moore, Margarett Shnorhavorian, Patricia Y. Fechner, Anne-Marie E. Amies Oelschlager, Justin A. Indyk, V. Rama Jayanthi, Hailey M. Umbaugh, Rachel Horton, Shira Kahn-Samuelson, Grace Raber, Madeline McClinchie, Kristina R. Olson   +16 more
doaj   +1 more source

Turning sex inside-out: Peripheral contributions to sexual differentiation of the central nervous system

Biology of Sex Differences, 2012
Sexual differentiation of the nervous system occurs via the interplay of genetics, endocrinology and social experience through development. Much of the research into mechanisms of sexual differentiation has been driven by an implicit theoretical ...
Swift-Gallant Ashlyn, Niel Lee, Monks D
doaj   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Sex Differences in NAFLD: State of the Art and Identification of Research Gaps

Hepatology, 2019
Despite tremendous research advancements in nonalcoholic fatty liver disease (NAFLD), our understanding of sex differences in NAFLD remains insufficient.
A. Lonardo, F. Nascimbeni, S. Ballestri, D. Fairweather, S. Win, T. Than, Manal F. Abdelmalek, A. Suzuki   +7 more
semanticscholar   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source