Results 111 to 120 of about 3,446,536 (312)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Intellectual disabilities moderate sex/gender differences in autism spectrum disorder: a systematic review and meta‐analysis [PDF]

, 2022
Emma Saure, Maija L. Castrén, Katri Mikkola, Juha Salmi   +3 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Turning sex inside-out: Peripheral contributions to sexual differentiation of the central nervous system

Biology of Sex Differences, 2012
Sexual differentiation of the nervous system occurs via the interplay of genetics, endocrinology and social experience through development. Much of the research into mechanisms of sexual differentiation has been driven by an implicit theoretical ...
Swift-Gallant Ashlyn, Niel Lee, Monks D
doaj   +1 more source

Sex Differences in Skin Tone Predicting Depressive Symptoms among College Students of Color [PDF]

, 2020
Sex Differences in Skin Tone Predicting Depressive Symptoms among College Students of Color Jenifer Rodriguez, Jenna Minter, Depts. of Psychology and Political Science, Eryn DeLaney, Dept. of Psychology Graduate Student, & Chloe Walker, Dept.
DeLaney, Eryn, Minter, Jenna, Rodriguez, Jenifer, Walker, Chloe   +3 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source

Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host

Aging and Cancer, EarlyView.
Colorectal cancer (CRC) mortality is highest in aged males. Pre‐clinical data comparing CRC i.p. metastasis in cohorts of young and aged, male and female mice support these finding. Bottom‐up proteomics of peritoneal mesothelial cells identified PTP4A1 as highly expressed in aged males and a role for PTP4A1 in heterotypic cell:cell adhesion was ...
Zhikun Wang, Yueying Liu, Jing Yang, Tyvette S. Hilliard, Reihaneh Safavi‐Sohi, Daniel D. Hu, Elizabeth I. Harper, Gena Dominique, Wanrui Wang, Jeffrey Johnson, Marwa Asem, William Milosevich, Julia Florek Carlson, Yunpeng Bai, Jinmin Miao, Zhong‐Yin Zhang, Matthew M. Champion, M. Sharon Stack   +17 more
wiley   +1 more source

Trends and Disparities in Lung Cancer and Respiratory Failure Mortality in the United States: A 24‐Year Retrospective Study

Aging and Cancer, EarlyView.
Mortality from lung cancer and respiratory failure in US adults declined until 2010 but increased thereafter, with notable disparities by sex, race, region, and urbanicity. This 24‐year analysis highlights rising post‐2010 mortality in women, non‐Hispanic Whites, and urban areas, underscoring the need for targeted public health interventions.
Sardar M. I. Khan, Muneeb Khawar, Abdul Qadeer, Aqsa Komel, Azka Aisha, Arshia Batool, Ayesha Fatima, Javed Iqbal, Asraf Hussain, Anisha Manzoor, Muhammad Waqas   +10 more
wiley   +1 more source