Results 61 to 70 of about 3,446,536 (312)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Sex differences in the impact of social determinants of health on substance use disorder treatment outcomes

Biology of Sex Differences
Background Social determinants of health (SDOH) and clinical severity factors are known to shape substance use disorder (SUD) treatment outcomes, yet limited research has explored how these influences differ by sex.
C. Leonardo Jimenez Chavez, MacKenzie R. Peltier, Sherry A. McKee   +2 more
doaj   +1 more source

Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics

Biology of Sex Differences, 2022
Highlights It is now established that men and women respond differently to infection from COVID-19 and that clinical outcomes from this infection are more severe in men.
R. Craig Stillwell
doaj   +1 more source

Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality [PDF]

, 2022
Alex R. DeCasien, Elisa Guma, Siyuan Liu, Armin Raznahan   +3 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women’s health cohort

Biology of Sex Differences
Background Hypertensive disorders of pregnancy (HDP) are associated with worse prenatal and perinatal sleep health and higher cardiovascular disease risk beyond the peripartum period.
Kimia Heydari, Sheryl L. Rifas-Shiman, Suzanne M. Bertisch, Elizabeth B. Klerman, Jorge E. Chavarro, Emily Oken, Karen M. Switkowski   +6 more
doaj   +1 more source

Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background

Biology of Sex Differences, 2022
Introduction CD44 is a candidate gene for obesity and diabetes development and may be a critical mediator of a systemic inflammation associated with obesity and diabetes.
Melissa VerHague, Jody Albright, Keri Barron, Myungsuk Kim, Brian J. Bennett   +4 more
doaj   +1 more source

Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes [PDF]

, 2010
There is evidence that female athletes may be more susceptible to exercise-induced arterial hypoxemia and expiratory flow limitation and have greater increases in operational lung volumes during exercise relative to men.
A. William Sheel, Baydur A, Donald C. McKenzie, Jeremy D. Road, Jordan A. Guenette, Jordan S. Querido, Lee M. Romer, Mead J, Neil D. Eves, Romeo Chua, Tarnopolsky MA   +10 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women

Biology of Sex Differences
Background There is no safe amount or time of alcohol consumption during pregnancy; however, many women drink while pregnant placing themselves and their fetuses at risk for alcohol-related health complications.
MacKenzie R. Peltier, Terril L. Verplaetse, Vera Bici, Abbie A. Mokwuah, C. Leonard Jimenez Chavez, Yasmin Zakiniaeiz, Robert Kohler, Vernon Garcia-Rivas, Bubu A. Banini, Hang Zhou, Nakul R. Raval, Brian Pittman, Sherry A. McKee   +12 more
doaj   +1 more source