Results 281 to 290 of about 4,165,700 (341)

Arsenicosis: sex differentials.

Journal of preventive and social medicine : JOPSOM : a bi-annual journal of the National Institute of Preventive and Social Medicine, 2000
S A, Ahmad, M H, Sayed, M H, Faruquee, M H, Khan, M A, Jalil, R, Ahmed, M A, Razzaque, , Moyeen-us-safa   +7 more
openaire   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

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Sex Determination, Gonadal Sex Differentiation and Pl--asticity in Vertebrate Species.

Physiological Reviews, 2020
A diverse array of sex determination (SD) mechanisms, encompassing environmental to genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD mechanisms (mammals) to functional sex change in fishes (sequential hermaphroditic ...
Y. Nagahama, T. Chakraborty, B. Paul-Prasanth, K. Ohta, Masaru Nakamura   +4 more
semanticscholar   +1 more source

Timing of gonadal development and dimorphic expression of sex-related genes in gonads during early sex differentiation in the Yellow River carp

, 2020
The common carp, a gonochoristic teleost fish with an XX/XY sex-determining system, provides an excellent model for studying cyprinidae gonadal sex differentiation.
Mouyan Jiang, Shaoting Jia, Ji Chen, Kuangxin Chen, Wenge Ma, Xingxing Wu, Hongrui Luo, Yongming Li, Zuoyan Zhu, Wei Hu   +9 more
semanticscholar   +1 more source

Abnormal sex differentiation

The Journal of Pediatrics, 1984
Rappel des connaissances actuelles sur les mecanismes de la differenciation sexuelle normale et revue des progres recemment accomplis dans l'analyse et le diagnostic des anomalies de cette differenciation par troubles de la synthese ou du metabolisme de la testosterone ou de l'action des androgenes, anomalies de la differenciation gonadique, presence d'
openaire   +2 more sources

Decoding Dmrt1: Insights into vertebrate sex determination and gonadal sex differentiation.

Journal of Evolutionary Biology
The Dmrt gene family is characterized by a conserved DM domain. It includes nine genes in vertebrates and is crucial to sex determination and sexual differentiation.
Barbora Augstenov'a, Wen-Juan Ma
semanticscholar   +1 more source

Abnormalities of Sex Differentiation

Hormone Research, 1996
Sex differentiation is determined by a cascade of events proceeding from chromosomal sex to the completion of sexual maturation at puberty. Many factors involved in this cascade have been identified. Here we focus on DAX-1, androgen receptor and cytochrome P450c17, and discuss their functions in sex differentiation.
H, Nawata, R, Takayanagi, T, Yanase, S, Ikuyama, T, Okabe   +4 more
openaire   +2 more sources

Sex Determination and Differentiation

New England Journal of Medicine, 2004
This review elucidates the molecular mechanisms of sex determination and sex differentiation with examples from embryology, animal models, and clinical syndromes. Sex reversal, defective masculinization, pseudohermaphroditism, and syndromes involving the gonads and other organs are some of the clinical problems discussed.
David T, MacLaughlin, Patricia K, Donahoe   +1 more
openaire   +2 more sources

A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish (Pelteobagrus fulvidraco).

Science Bulletin, 2018
The sex-determining genes are found to be variable among different fish species. Yellow catfish (Pelteobagrus fulvidraco) is an important aquaculture fish species in China with XX/XY sex-determining type.
Cheng Dan, Qiaohong Lin, Gaorui Gong, T. Yang, Shuting Xiong, Yang Xiong, Peipei Huang, J. Gui, Jie Mei   +8 more
semanticscholar   +1 more source