Results 121 to 130 of about 3,770,529 (313)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

'My Bed or Our Bed?': Gendered Negotiations in the Sleep of Same-Sex Couples [PDF]

Sexuality as well as gender can be added to the range of socio-structural factors that influence the social patterning of sleep. This paper draws on in-depth interviews with 20 women and men aged between 45 – 65 years in same-sex couple relationships to ...
Allison Kirkman
core  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Investigating how blood cadmium levels influence cardiovascular health scores across sexes and dose responses

Frontiers in Public Health
BackgroundThe association between exposure to cadmium (Cd) and cardiovascular health (CVH) has received considerable scientific interest. However, findings thus far have been inconclusive, particularly regarding sex-specific effects and dose–response ...
Feng Chen, Feng Chen, Hao Lin, Yuansi Zhang, Yu Zhang, Shaohe Chen   +5 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Changing Academic Environment and Diversity in Students’ Study Philosophy, Beliefs, and Attitudes in Higher Education [PDF]

The diversity of students in higher education in Australia and elsewhere has changed significantly over the past two decades. The existing literature has provided limited clarity in terms of their effects on teaching and learning or on the way in which ...
Adrian Ashman, Mohammad Alauddinh
core  

Sex Offender Treatment Project: Literature Review [PDF]

, 1994
A comprehensive literature review on recidivism by and the treatment of sex offenders.Alaska Department of CorrectionsAcknowledgements / Introduction / Recidivism / Treatment — Voluntary Vs. Involuntary, Treated Vs.
Baca, Melanie, Barnes, Allan R., Dix, Melody, Flahr, Shelly, Gaal, Cathy, Moeglein, Samantha, Morgheim, Nicol, Whitaker, Max   +7 more
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Misperception in Heart Failure Phenotyping: Moving Beyond the Chamber to the Myocardium

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Left ventricular ejection fraction (LVEF) remains the cornerstone of heart failure (HF) phenotyping, yet it weakly correlates with outcomes and may overestimate systolic function, especially in elderly women with altered left ventricular ...
Jiesuck Park, Jaehyun Lim, In‐Chang Hwang, Jin‐Joo Park, Jun‐Bean Park, Jae‐Hyeong Park, Goo‐Yeong Cho   +6 more
doaj   +1 more source