Results 1 to 10 of about 60,867 (320)

Sex hormone-binding globulin and arthritis: a Mendelian randomization study [PDF]

Arthritis Research & Therapy, 2020
Background Sex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so of three common forms of arthritis: osteoarthritis (OA), rheumatoid arthritis (RA),
Zihao Qu, Jiawei Huang, Fangkun Yang, Jianqiao Hong, Wei Wang, Shigui Yan   +5 more
doaj   +3 more sources

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis [PDF]

Scientific Reports, 2016
Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues.
Michaël R. Laurent, Geoffrey L. Hammond, Marco Blokland, Ferran Jardí, Leen Antonio, Vanessa Dubois, R Khalil, Saskia S. Sterk, Evelien Gielen, Brigitte Decallonne, Geert Carmeliet, Jean‐Marc Kaufman, Tom Fiers, Ilpo Huhtaniemi, Dirk Vanderschueren, Frank Claessens   +15 more
core   +5 more sources

Sex hormone binding globulin and insulin resistance [PDF]

Clinical Endocrinology, 2013
SummarySex hormone binding globulin (SHBG) is a glycoprotein composed of two 373‐amino‐acid subunits. The SHBG gene and a promotor region have been identified. The SHBG receptor has yet to be cloned but is known to act through a G‐protein‐linked second‐messenger system following plasma membrane binding.
Wallace, Ian R, McKinley, Michelle C, Bell, Patrick M, Hunter, Steven J   +3 more
exaly   +5 more sources

Association of age and insulin resistance with sex hormone-binding globulin levels in healthy men [PDF]

Archives of Endocrinology and Metabolism
Objective: To evaluate the putative association of age and insulin resistance with sex hormone-binding globulin levels in healthy men. Methods: In total, 136 healthy men without obesity, aged 18 years or older, were included.
Indianara Franciele Porgere, Bruna Martins Rocha, Gustavo Monteiro Escott, Luiza Carolina Fagundes Silva, Priscila Aparecida Correa Freitas, Fabíola Satler, Sandra Pinho Silveiro   +6 more
doaj   +2 more sources

Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes [PDF]

Molecular Metabolism
Regulation of lipid metabolism is fundamental for metabolic health, and adipose tissue is a central component in this process. Adipose tissue differs considerably between women and men in terms of a higher subcutaneous capacity for storage, which is ...
Julie Abildgaard, Aiste Aleliunaite, Carla Horvath, Nagendra Palani, Tora Ida Henriksen, Jiawei Zhong, Katja Munch Lorentsen, Victor Svenstrup, Hanne Frederiksen, Anders Juul, Camilla Charlotte Scheele, Søren Nielsen   +11 more
doaj   +2 more sources

Sex-specific associations of sex hormone binding globulin and risk of bladder cancer [PDF]

Open Medicine
Males have a three times higher risk of a diagnosis of bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be associated with Bca risk. However, the sex-specific role of SHBG in Bca remains unclear.
Ou Junyong, Bi Hai, Zhou Haobin, Zhang Zhanyi, Duan Peichen, Yin Haoming, Zhou Zezhen, Xie Zhixin, Tian Xiaojun, Ye Jianfei, Zhang Shudong   +10 more
doaj   +2 more sources

The Association of Low Muscle Mass With Serum Sex Hormones and Sex Hormone‐Binding Globulin [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background The purpose of this study was to explore the associations of low muscle mass with serum sex hormones and sex hormone‐binding globulin (SHBG) using data from the National Health and Nutrition Examination Survey (NHANES).
Hailin Qin, Wenyong Jiao, Gui Liao
doaj   +2 more sources

SINGLE NUCLEOTIDE POLYMORPHISMS (CYP11 ALPHA AND CYP17) AND SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN NORMAL AND POLYCYSTIC OVARY SYNDROME

Pakistan Armed Forces Medical Journal, 2021
Objective: To examine the potential association between CYP11 alpha and CYP17 polymorphism, and serum sex hormone binding globulin (SHBG) levels and their possible contribution to polycystic ovary syndrome. Study Design: Case control study.
Nauman Aziz, Shamaila Doggar, Amer Shoaib, Muhammad Saeed Aslam, Muhammad Omer Altaf   +4 more
doaj   +1 more source

Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk [PDF]

Life
In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBGcon) and uterine fibroids (UFs).
Marina Ponomarenko, Evgeny Reshetnikov, Maria Churnosova, Inna Aristova, Maria Abramova, Vitaly Novakov, Vladimir Churnosov, Alexey Polonikov, Denis Plotnikov, Mikhail Churnosov, Irina Ponomarenko   +10 more
doaj   +2 more sources

The relationship between Components of Metabolic Syndrome and Plasma Level of Sex Hormone-Binding Globulin

European Journal of Translational Myology, 2019
Plasma concentration of sex hormone-binding globulin (SHBG), as an androgen binding protein, is impressed by many physiological and environmental factors.
Amin Alinezhad, Fatemeh Jafari
doaj   +3 more sources